18 4714105
fax: +46 18 471 4003
From: Mats Karlsson [mailto:mats.karls...@farmbio.uu.se]
Sent: Tuesday, June 01, 2010 4:03 PM
To: 'Nick Holford'; 'nmusers@globomaxnm.com'
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM
Nick,
I don’t think the design
Dear Ethan,
I am not 100% on exactly who said what in this thread and do not want to
put my words in anyone else's mouth, but I think we can all agree on
this:
* In simulation mode NONMEM assumes a normal distribution of etas
* In estimation mode omega can be seen as an estimate of
will leave the interpretation to the rest of you.
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Ethan Wu
Sent: Tuesday, June 01, 2010 10:04 AM
To: Ribbing, Jakob; nmusers
Subject: Re: [NMusers] distribution assumption of Eta in NONM
ubject: RE: [NMusers] distribution assumption of Eta in NONMEM
Dear all,
Dropping in a little late in the game all I can say is this:
Shame on all you great minds for reinventing your own wisdom :>)
Most of the content in the current thread has already been discussed in an
earlier thread:
ht
Dear all,
Dropping in a little late in the game all I can say is this:
Shame on all you great minds for reinventing your own wisdom :>)
Most of the content in the current thread has already been discussed in
an earlier thread:
http://www.mail-archive.com/nmusers@globomaxnm.com/msg01271.ht
f Leonid Gibiansky
Sent: Monday, 31 May, 2010 23:31
To: Nick Holford; nmusers
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
Nick,
I think, transformation idea is the following:
Assume that your (true) model is
CL=POPCL*exp(ETAunif)
where ETAunif is the random variable with
: nmusers@globomaxnm.com
Cc: 'Marc Lavielle'
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
Mats,
I agree that trying to learn anything from the EBE distribution is a largely
uninformative activity. If the shrinkage is too small then the EBEs are driven
primarily b
---
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Michael Fossler
Sent: Tuesday, 01 June, 2010 3:54
To: Leonid Gibiansky; Nick Holford; nmusers
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM
Interesting topic. Can anyone provide
, June 01, 2010 3:54 AM
To: Leonid Gibiansky; Nick Holford; nmusers
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM
Interesting topic. Can anyone provide specific transformations of ETAs that
they have found useful?
Mike Fossler
GSK
-Original Message-
From: owner-nmus
Holford; nmusers
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
Nick,
I think, transformation idea is the following:
Assume that your (true) model is
CL=POPCL*exp(ETAunif)
where ETAunif is the random variable with uniform distribution.
Assume that you have transformation TRANS
[mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Nick Holford
*Sent:* Monday, May 31, 2010 6:05 PM
*To:* nmusers@globomaxnm.com
*Cc:* 'Marc Lavielle'
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
Hi,
I tried to see with brute force how well NONMEM can produce an
emp
*Cc:* 'Marc Lavielle'
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
Hi,
I tried to see with brute force how well NONMEM can produce an
empirical Bayes estimate when the ETA used for simulation is
uniform. I attempted to stress NONMEM with a non-linear problem
Sorry - I misread my results. The ETA shrinkage was -0.4% not -40%. I
had forgotten that NONMEM reports the shrinkage as a % not as a fraction.
Nick Holford wrote:
Mats,
I agree that trying to learn anything from the EBE distribution is a
largely uninformative activity. If the shrinkage is t
:* nmusers@globomaxnm.com
*Cc:* 'Marc Lavielle'
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
Hi,
I tried to see with brute force how well NONMEM can produce an
empirical Bayes estimate when the ETA used for simulation is uniform.
I attempted to stress NONMEM with
:* Monday, May 31, 2010 6:05 PM
*To:* nmusers@globomaxnm.com
*Cc:* 'Marc Lavielle'
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
Hi,
I tried to see with brute force how well NONMEM can produce an
empirical Bayes estimate when the ETA used for simulation is uni
owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Nick Holford
*Sent:* Monday, May 31, 2010 6:05 PM
*To:* nmusers@globomaxnm.com
*Cc:* 'Marc Lavielle'
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
Hi,
I tried to see with brute force how wel
, May 31, 2010 6:05 PM
To: nmusers@globomaxnm.com
Cc: 'Marc Lavielle'
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
Hi,
I tried to see with brute force how well NONMEM can produce an empirical Bayes
estimate when the ETA used for simulation is uniform. I attempted
Hi,
I tried to see with brute force how well NONMEM can produce an empirical
Bayes estimate when the ETA used for simulation is uniform. I attempted
to stress NONMEM with a non-linear problem (the average DV is 0.62). The
mean estimate of OMEGA(1) was 0.0827 compared with the theoretical value
:46 AM
*To:* nmusers@globomaxnm.com
*Cc:* 'Marc Lavielle'
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
Mats,
This is a helpful and interesting response but I think it is an answer
to a different kind of question. My understanding of the original
question wa
: +46 18 471 4003
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Sunday, May 30, 2010 9:46 AM
To: nmusers@globomaxnm.com
Cc: 'Marc Lavielle'
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
Mats,
This is a h
of Pharmaceutical Biosciences
Uppsala University
Box 591
751 24 Uppsala Sweden
phone: +46 18 4714105
fax: +46 18 471 4003
*From:* owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Eleveld, DJ
*Sent:* Sunday, May 30, 2010 1:20 AM
*To:* Nick Holford; nmusers@glo
m:* owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Eleveld, DJ
*Sent:* Sunday, May 30, 2010 1:20 AM
*To:* Nick Holford; nmusers@globomaxnm.com
*Cc:* Marc Lavielle
*Subject:* RE: [NMusers] distribution assumption of Eta in NONMEM
I'd like to interject a
Douglas,
Thanks for your thoughtful and insightful comments on why anyone might
be interested in the answer to the question "Does NONMEM assume a normal
distribution for estimation?".
In fact one has no choice but to use whatever assumptions are built into
the estimation algorithm. So a more
Nick Holford; nmusers@globomaxnm.com
Cc: Marc Lavielle
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM
I'd like to interject a slightly different point of view to the distributional
assumption question here.
When I hear people speak in terms of the “distribution assumption
I'd like to interject a slightly different point of view to the distributional
assumption question here.
When I hear people speak in terms of the distribution assumptions of some
estimation method I think its easy for people to jump to the conclusion that
the normal distribution assumptio
...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Jurgen Bulitta
Sent: Friday, May 28, 2010 11:50 PM
To: 'nmusers@globomaxnm.com'
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM
Dear Ethan,
There may be two aspects to your question, one is on the
assu
m.com] On
Behalf Of Nick Holford [n.holf...@auckland.ac.nz]
*Sent:* Friday, May 28, 2010 2:50 PM
*To:* nmusers@globomaxnm.com
*Subject:* Re: [NMusers] distribution assumption of Eta in NONMEM
For estimation NONMEM estimates one parameter to describe the
distribution of random effects -- this i
ms Analysis.
vol. 2. Boston, MA : Kluwer Academic Publishers ; 1995 :145- 160.
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Friday, May 28, 2010 3:51 PM
To: nmusers@globomaxnm.com
Subject: Re: [NMusers] distribution assumption of Eta in NON
, 2010 2:27 PM
To: Serge Guzy; nmusers@globomaxnm.com
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
I could not find in the NONMEM help guide that explicitly mentioned a normal
distribution is assumed, only it was clearly mentioned of assumption of mean of
zero
of mean of zero.
*From:* Serge Guzy
*To:* Ethan Wu ; nmusers@globomaxnm.com
*Sent:* Fri, May 28, 2010 1:25:24 PM
*Subject:* RE: [NMusers] distribution assumption of Eta in NONMEM
As far as I know, this is the assumption in
Guzy; nmusers@globomaxnm.com
Subject: Re: [NMusers] distribution assumption of Eta in NONMEM
I could not find in the NONMEM help guide that explicitly mentioned a normal
distribution is assumed, only it was clearly mentioned of assumption of mean
of zero.
_
From: Serge Guzy
To
Subject: RE: [NMusers] distribution assumption of Eta in NONMEM
As far as I know, this is the assumption in most of the population programs
like NONMEM, SADAPT, PDX-MC-PEM and SAEM. Therefore when you simulate, random
values from a normal distribution are generated. However, you have the
flexibility
] distribution assumption of Eta in NONMEM
Dear users,
Is it true NONMEM dose not assume Eta a normal distribution?
If it does not, I wonder what distribution it assumes? I guess this is
critical when we do simulations.
Thanks
--
The information contained in this email message may
Dear users,
Is it true NONMEM dose not assume Eta a normal distribution?
If it does not, I wonder what distribution it assumes? I guess this is
critical when we do simulations.
Thanks
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