RE: [NMusers] unbalanced design

e. -Original Message- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] Behalf Of Mats Karlsson Sent: Tuesday, September 02, 2008 22:53 PM To: 'Nick Holford'; 'Wang, Yaning' Cc: 'Mark Sale - Next Level Solutions'; nmusers@globomaxnm.com Subject: RE: [NMus

RE: [NMusers] unbalanced design

ons; nmusers@globomaxnm.com Subject: Re: [NMusers] unbalanced design Hi, Its not clear to me what Mark had in mind when he asked if " mixed effect modeling (NONMEM in particular) is robust". But Susan proposes its just obviously OK and Yaning suggests reading a book for the simple ca

Re: [NMusers] unbalanced design

Hi, Its not clear to me what Mark had in mind when he asked if " mixed effect modeling (NONMEM in particular) is robust". But Susan proposes its just obviously OK and Yaning suggests reading a book for the simple case of linear models. But what about the real world i.e. non-linear mixed mod

RE: [NMusers] unbalanced design

Linear Mixed Models for Longitudinal Data by Geert Verbeke , Geert Molenberghs

RE: [NMusers] unbalanced design

Hi Mark, This should be true just based on the nature of mixed effects modeling. If you are not convinced, you may want to try some examples where you simulate balanced and unbalanced designs and then estimate. :-) Best Regards, Susan From: [EMAIL