On Wed, Jan 10, 2007 at 01:20:12PM +0530, Aditya Kapil wrote: > This does'nt tell me if there is a crystal structure. Is there one? Ion > channels have proved hard to crystallize. Rod McKinnon who managed to do
Transmembrane-anything is hard to crystallize, for obvious reasons. Water is not their native habitat. > elucidate the potassium channel crystal structure was awarded the Nobel for > his efforts. Without the crystal structure it's hard to design inhibitiors. Actually, typically having even a very good crystal structure doesn't buy you all that much. Most good drugs these days come from library screens, and typically, they're good libraries to start with. > In context of earlier mails, these would be excellent for pain relief. This has been mentioned already, and has generated some excitement. -- Eugen* Leitl <a href="http://leitl.org";>leitl</a> http://leitl.org ______________________________________________________________ ICBM: 48.07100, 11.36820 http://www.ativel.com 8B29F6BE: 099D 78BA 2FD3 B014 B08A 7779 75B0 2443 8B29 F6BE
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