Doug,
I hope you don't mind another kibitzing input for what was a message to Brooks.
The length of time release in the study you referenced is impressive. I think
you have a good idea. However, I might suggest using silver citrate over EIS or
colloidal silver in this application. Silver citrate can be made in higher
concentrations. Tests have shown that it can even be reduced to a powder and
reconstituted. It also has demonstrated a high antimicrobial capability. It
might be a good fit for your application.
Best of luck,
Steve N
On Tue, Jan 19, 2010 at 9:47 AM, polo <dah...@centurytel.net> wrote:
> Hopefully Brooks will have time to consider and comment on this.
>
> I have long been interested in protocols that will efficiently attack
> biofilm infections. It seems that inhaled (nebulized) liposomal
> medications are very effective in penetrating very difficult to treat lung
> biofilms. Some recent studies have suggested that liposomal antibiotics are
> superb treatments. Here is one:
>
> http://jac.oxfordjournals.org/cgi/content/full/61/4/859
>
>
> The above study used a compressor type of nebulizer (nebulizer PARI LC
> Star). Anyway, I would like to try liposomal colloidal silver in a
> nebulizer for biofilm lung infections, particularly in racehorses. Normally
> we use ultrasonic nebulizers as opposed to the older compressor type
> nebulizers as was used in the above study. Ultrasound nebulizers vaporize
> the medication into super small droplets that can be pushed into the lung
> via an air jet. The older compressor type uses a small air compressor to
> vaporize the inhaled medication producing larger medication particles to be
> breathed in. Naturally, the ultrasound nebulizer technology produces small
> droplet size which is more conducive to lung inhalation efficacy.
>
> What I would like to know, do you see any problems with producing
> colloidal silver liposomes using your home made protocol and (2) would an
> ultrasonic nebulizer be detrimental to the liposomal structure? Would an
> older compressor type nebulizer as used in the study be better in putting
> liposomes into solution for inhalation purposes or would the newer utrasonic
> nebulizers not over-whelming affect liposomal structure upon vaporzation or
> might it even be beneficial?
>
> As a side note, I want to add that heavy metals seem particularly
> effective against biofilms of which I would venture a guess that colloidal
> silver would be a superb medication, if one could only get it to be absorbed
> by the biofilm. Liposomal technology may be the key!
>
> doug
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