Hi, you can convert the raw data to mzML on any computer that runs docker. 
E.g. I use this strategy to convert Thermo files on a Linux System. The 
chambm container simulates a Windows system and contains the necessary 
vendor libraries. My command looks like this from the command line:

docker run -it -v /home/antix/Downloads/ThermoDDA:/data 
chambm/pwiz-skyline-i-agree-to-the-vendor-licenses wine msconvert 
/data/*.raw

Best, Robert
On Wednesday, 27 November 2024 at 12:00:18 UTC-6 David Shteynberg wrote:

> Hello Arpita,
>
> Unfortunately, DLL files are Windows specific and do not function on Mac.  
> Whether or not Thermo is planning on providing RAW data access libraries 
> that function on Mac is a question for Thermo, but I suspect this is not a 
> top priority for most customers.  I hope you are able to convert your data 
> to open formats on another computer and then continue using the TPP on your 
> Mac.
>
> Best,
> -David
>
> On Tue, Nov 26, 2024 at 8:37 PM 'ARPITA TIWARI' via spctools-discuss <
> [email protected]> wrote:
>
>> Sorry to disturb you but can I know why is it not possible on Mac? Why 
>> does Thermo libraries work in windows only? Is there any other solution ?
>> Best regards
>> Arpita 
>>
>> On Wed, Nov 27, 2024 at 9:20 AM ARPITA TIWARI <[email protected]> 
>> wrote:
>>
>>> Dear David,
>>> Okay will do that, thank you so much for your response.
>>> Best regards
>>> Arpita
>>>
>>> On Wed, Nov 27, 2024 at 9:01 AM 'David Shteynberg' via spctools-discuss <
>>> [email protected]> wrote:
>>>
>>>> Hello Arpita,
>>>>
>>>> Thanks for your question.  Conversion from RAW happens with the help of 
>>>> Thermo dll libraries which only function on windows.  To process 
>>>> proteomics 
>>>> data with TPP on a Mac you have to start with mzML or mzXML data and 
>>>> convert the data on another computer.
>>>>
>>>> Best,
>>>> David
>>>>
>>>>
>>>> On Tue, Nov 26, 2024, 7:27 PM 'ARPITA TIWARI' via spctools-discuss <
>>>> [email protected]> wrote:
>>>>
>>>>> Hello everyone, 
>>>>> I have attached the following error below I have installed the TPP in 
>>>>> M1 MAC os with the help of source link. Now I am trying to convert .raw 
>>>>> file into mxML. Somehow, it isn"t happening.
>>>>> I will be grateful if anyone an solve this problem. 
>>>>> Thank you 
>>>>> Best regards
>>>>> Arpita
>>>>> [image: Screenshot 2024-11-27 at 7.43.09 AM.png][image: Screenshot 
>>>>> 2024-11-27 at 8.29.55 AM.png]
>>>>>
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