Rob Willett <rob.sqlite at ...> writes:

[snip]
> The headline figures are we have gone from 213 secs to process 20 files
down to 90 secs to process 20 files. We
> are running approx 2.5x faster. To get this improvement the biggest change
was simply adding COLLATE
> NOCASE to the table schema. This saved around 120-130 secs which was
brilliant. 
> 

Did you consider putting all SELECT-statements in an explicit transaction
(BEGIN TRANSACTION / COMMIT) ? When the statements are in one transaction,
sqlite only needs to acquire/release the lock once. During some benchmark
tests I did a few years ago, this reduced query time from 640 ms to 210 ms
for 10 000 trivial SELECT statements.

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