I have used SynaSer successfully with USB serial ports on Windows 95 upwards. 
No fancy coding, I just followed the basic example.

> At the moment I can connect to the real COM1 ok but any
> attempts to connect to COM5 are failing (using SysInternals
> portmon, it recognises that COM5 exists but when I monitor
> it there is no use shown on that port).

Are you sure that the port is not in use? PortMon is always my first 
troubleshooting tool.

Did you know that you can change the COM port? Here is how to do it in Windows 
XP:

In device manager, get the properties for the port, then go to Port Settings -> 
Advanced. You can then check or change the port number allocation (COM1 to 
COM256!).

Hope that helps.




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