On 17 Dec 2009 at 22:15, Jim Clark wrote:
> 
> The level of lactose intolerance (in modern times at least) is quite low for 
> UK (presumably Caucasians?),
> which leads one to wonder about its a priori probability as a disorder for 
> Darwin. 

When I said "while he [John Hayman, the author of the recent 
BMJ article on Darwin's illness] seems to agree that the lactose 
(or milk protein) intolerance theory does have merit", I wasn't 
erroneously claiming that lactose is milk protein, because 
lactose is, of course, milk sugar.  But I was too brief to be 
understandable.

What Hayman said in his note to me was that he thought that 
Darwin may have had an allergy to milk protein rather than to 
lactose. It's regrettable he couldn't find a place for his views on 
this in his published paper.

> It also allows one to make the point that genetic does NOT
> equal immutable, perhaps another factor in student resistance to genetic 
> hypotheses. 

I must demur, although perhaps only to the way this is 
expressed. Genetic causation does mean immutable. It is 
possible  to reduce or prevent the secondary consequences of 
the genetic specification (a trivial example would be hair dye for 
people suffering from red hair; a non-trivial example the special 
diet used to treat PKU) but the genetic basis remains 
unchanged. It's still red under the blonde hair dye; the individual 
with PKU still can't metabolize phenylalanine. 

It is true that we are on the cusp of real genetic change through 
gene therapy; it may already be here in a few extraordinary  
cases. But in general, while we can ameliorate the 
consequences of a genetic specification, we cannot change the 
specification nor its direct consequence.

Cautious note to the red-haired. I joke. I have nothing against 
red hair. Indeed, some of my best friends have red hair. 

Stephen

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Stephen L. Black, Ph.D.          
Professor of Psychology, Emeritus   
Bishop's University               
 e-mail:  sbl...@ubishops.ca
2600 College St.
Sherbrooke QC  J1M 1Z7
Canada
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