Hello Everyone,
   
  When I refined a structure, I found strong difference density Fo-Fc at 3 
sigma contour for the for five residues which already have occupancy of 1. The 
density is continuous and so strong as if I did not put the residues there. Why 
was that? Can I put greater than 1 occupancy for those residues? 
   
  Thank you very much for your opinions and suggestions!
   
  Best wishes,
   
  Sun Tang

       
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