I like your point--somehow we should enlist the evil inclination to power our science, a la Faust. How is it that those hackers are so innovative for so little reward? I remember a Smithsonian article years ago which quoted the calculated mean $/hr rate of money counterfeiters as being ~pennies/hr, and I assume hackers would fit right in there...
JPK On Sun, Apr 1, 2012 at 11:45 PM, Artem Evdokimov <artem.evdoki...@gmail.com>wrote: > I can't resist asking: If we assume that the data fabrication > techniques and the techniques for discovery of such activities should > have the same sort of arms race as the development of viruses and > anti-malvare software (but of course on a much more modest scale since > structural biology is a relatively niche discipline) - can we then > speculate further that eventually the most sophisticated fabrication > techniques would be equivalent to de novo structure prediction :) It's > really too bad that there's no real money in this (again, relatively > speaking - not as much money as there is in software development), > because if there was then the structural biology equivalent of 'virus > hackers' would in reality approximate the same development trajectory > as the most successful (and legitimate) protein modelers. Given the > ingenuity of hackers and like-minded people in general, I sometimes > wonder if this isn't a better way to develop structure prediction > tools... > > Artem > > On Sun, Apr 1, 2012 at 10:09 AM, Paul Emsley <paul.ems...@bioch.ox.ac.uk> > wrote: > > On 31/03/12 23:08, Kevin Jin wrote: > > > > > > I really wish PDB could have some people to review those important > > structures, like paper reviewer. > > > > > > So do the wwPDB, I would imagine. > > > > But they can't just magic funding and positions into existence... > > > > If the coordinate is downloaded for modeling and docking, people may not > > check the density and model by themself. However this is not the worst > case, > > since the original data was fabricated. > > > > > > 1. All of data was correct and real, > > > > > > Hmmm... > > > > It will be very difficult for people to check the density and > coordinated > > if he/she is not a well-trained crystallographer. > > > > > > I hope and believe that this is not the case. Even basically-trained > > crystallographers should be able to calculate and interpret difference > maps > > of the kind described by Bernhard. And with the EDS and PDB_REDO server, > > one does not even need to know how to make generate a difference map... > > > > Paul. > > > > > -- ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program email: j-kell...@northwestern.edu *******************************************
