This may be somethng similar
Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet
structure.
Spinelli S, Desmyter A, Frenken L, Verrips T, Tegoni M, Cambillau C.
FEBS Lett. 2004 Apr 23;564(1-2):35-40.
Remy Loris
Vrije Universiteit Brussel
On 18/06/12 15:49, anna anna wrote:
Hi all!
I'd like your opinion about a structure I solved.
Apart from protein structure itself, I think that my protein xtallized
in an odd way!
The biological unit is a dimer while the asymmetric unit is a tetramer
(red cartoon in the figure) resulting from domain swapping between two
dimers.
The strange thing is that swapping connects infinite monomers and,
rather than a xtal, my diffracting object seems a multilayer of
endless linear polymers, a kind of papyrus with greek fret-like
fibers. The figure shows the orientation of the polymers in each layer.
I'd like to know if some of you have already seen a similar pattern or
it is weird as I think!
I'm further racking my brain to figure out a biological implication of
this behaviour, I thought something like plaque formation but I can't
find support in literature.
All suggestions are welcome!!
Cheers,
Anna
