Sample manipulation on the part of the drug company (actually quite common)?
Random variation - a lot of research shows that this accounts for most intra study variation. Subject Characteristics - what was different about the sample - i.e., were the people in the 10th study more or less sick than those who were in the other 9 (also common in drug company research). Experiment characteristics - were those administering the drugs and the placebo blind to the different conditions? etc., etc., etc... There are just tons of reasons why. On Mon, Aug 16, 2010 at 2:42 PM, G Money <gm0n3...@gmail.com> wrote: > > On Mon, Aug 16, 2010 at 1:38 PM, Judah McAuley <ju...@wiredotter.com> wrote: > >> >> As an aside about drug research, pharmaceutical companies only have to >> publish and submit the reports they want regarding a drug. A pharma >> company can do 10 studies on a drug, 9 of which show no positive >> difference and 1 that does and then simply submit the 1 study that >> does show a positive difference. The FDA can say "well, one study >> isn't a sufficient amount" and wait for further research, but the drug >> company is currently under no obligation to tell the FDA that they did >> 9 other studies already that didn't back up the claims they make in >> their FDA application. >> >> The FDA doesn't do independent clinical trails. They rely upon the >> data given to them and that data is carefully selected to put the most >> positive light on an application. Something to consider when you start >> thinking about the process behind new drugs and the FDA. >> > > I don't necessarily have a problem with that...let the companies spend the > time and money to do the research, and then let the FDA ensure that > everything is on the up and up. > > I'd be curious how, if...and this might be a big IF...if all 10 trials were > on the up and up, why 9 would fail, and then suddenly 1 would succeed???? > Shouldn't they either all corroborate, or all refute....if all proper > variables are accounted for??? > > -- > No matter how close to yours another's steps have grown > In the end there is one dance you'll do alone > > > ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~| Order the Adobe Coldfusion Anthology now! http://www.amazon.com/Adobe-Coldfusion-Anthology-Michael-Dinowitz/dp/1430272155/?tag=houseoffusion Archive: http://www.houseoffusion.com/groups/cf-community/message.cfm/messageid:325238 Subscription: http://www.houseoffusion.com/groups/cf-community/subscribe.cfm Unsubscribe: http://www.houseoffusion.com/groups/cf-community/unsubscribe.cfm
