Flex calling a framework is a nice feature. Model-Glue, unless it has changed recently, takes advantage of ColdSpring.
Using the RemoteObjectProxy in ColdSpring made it pretty simple to create a webservice that calls the result of several dependent CFC objects created in the application to be available as a webservice. The RemoteObjectProxy also obfuscates the original CFC and it dependent objects as the invocation code doesn't exist in the generated proxy. I see from the ColdBox architectural framework graphic that ColdBox mentions LightWire. I would have to see how this would be achieved in LightWire. So, without using a Flex framework, my CFC calls are definitely made easier when I consume a RemoteObject in Flex. The caveat here is that ColdSpring or LightWire is YAF (Yet Another Framework). Teddy