For stock web serving stuff, like what you list, we use the Amazon Linux AMI.  
Amazon handles the optimization and compatibility issues and they are pretty 
responsive about adding new packages to the distribution.

For more specialized applications (VoIP infrastructure, XMPP server), where 
Amazon doesn't have packages already in the distro we use CentOS.

If your time is limited, I'd also recommend using Amazon RDS rather than 
managing your own MySQL server.

--
Eric Chamberlain, Founder
RingFree Mobility Inc.

On Nov 13, 2011, at 11:56 AM, ydjango wrote:

> I am setting up nginex, apache, python django, mysql based application
> on EC2. I expect high web traffic and high mysql query usage. Mysql
> and web server will on seperate servers.
> 
> Which linux distro should I use for heavy production use - Ubuntu,
> Centos or Debian?
> 
> Does it matter?
> 
> I see most instructions on web is using Ubuntu and it seems it is
> considered easiest to set up. But I read somewhere that Ubuntu is not
> for server use. What is the downside if I chose ubuntu?
> 
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