Do you think AZT could be used for cats with the herpes virus?
  tonya

jb...@tds.net wrote:
  Graca,

Hello. I responded to your email earlier but had some problems with my email 
and am not sure if you received it. This is basically what I said. If you get 
two emails for this sorry.

AZT is an antiviral used in human medicine to treat HIV. It is generally used 
in combination with other antivirals. Unfortunately, these combinations of 
antivirals have not been found to be effective against felv in cats. At least 
there are no good studies to support that.

AZT is often not used or stopped in people because it often causes anemia and 
bone marrow toxicity. This is a very widely known side effect of AZT. For this 
reason, I would listen to the vet that suggests stopping the AZT.

Since anemia can be a common symptom of felv and your cat is experiencing it. 
It is either because of progression of the felv disease or a side effect of the 
drugs. If it is the drug, stop giving it and the anemia should improve (this 
can be monitored by looking at the blood for reticulocytes - which are like 
baby red blood cells and indicate that the bone marrow is trying to fix the 
anemia - this is a good sign). If it is the felv disease progressing than the 
AZT is not really helping you anyway and there isn't much reason to continue 
giving it.

If you want to continue to treat the felv virus, there is a lot of buzz about 
something called Imulan. It is the first FDA approved drug for the treatment of 
felv/fiv in the United States. You may want to ask your vet about this 
possibility. It may be beneficial to stop your current meds and try this. I 
don't know. It would be trial and error. Keep in mind that anemia and bone 
marrow suppression in a felv positive cat is a poor prognostic sign.

In general, if it were me, I would stop the AZT and watch for improvement of 
the anemia. I may add Imulan (I have no experience with this drug yet), would 
consider a blood transfusion, from an immunized cat, if the anemia is 
significant enough and transfer factor if there is GI upset.

Hope this helps.

Jenny 
---- Graca Azevedo wrote: 
> 
Dear All,
 
I was so upset with my sick cat that I did not introduce myself as new to list 
a few days ago.  I do apologize.  I am writing from Brazil, have two rescued 
cats.  One of them is Felv+.  He has been treated on AZT and interferon for 2 
years and half. The virus reached his bone marrow and he has anemia.  Two vets 
have examined him.  One said that I should stop with the AZT and the other 
advised to continue.  I failed to find on the mail archives any report on cats 
being treated with AZT.
I would be most grateful to hear what any of you have to say.
 
Regards,

Graça Azevedo


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