Gary, After reading a number of papers, especially those by the research team of team of Dr. Robert Good, I decided for the following protocol: Staphylococcus Protein A (10 μg/kg twice per week for up to ten weeks), that is the same given in the ABCD guidelines on Feline Leukaemia Virus: http://www.vetscite.org/publish/articles/000072/article.pdf 1 mg of Protein A is diluted in 100 ml of saline solution. The resulting solution (stored at the freezer in 5ml aliquots) is injected IP (at a dosage of 1 ml per Kg).
http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2008&PID=23983&O=Generic see also http://www.felineleukemia.info/staphproteinacowan1.htm We cannot forget that this is a vastly investigated area, mainly due to implications of FeLV as a model to the research on human acquired immunodeficiency syndrome. Therefore, one may simply assume that after many years, a great discovery would have already happened if SPA therapy really holds any effect. The hopeful cases of FeLV remission reported in those papers may be due to other factors unsuspected at that time (for example, we now known that the different retroviral lineages lead to different outcomes of the disease). I don't believe a true remission can be achieved with SPA. I just think that the early finds derived from complex experiments (Liu et al.1984, Proc Natl Acad Sci U S A. 81:3516-3520 and 81:6471-6475; Engelman et al.1987, Cancer Detect Prev. 10:435-444; Snyder et al.1989 Semin Hematol. 26:25-30) could be readly disproved by a the simple controlled trial conduced latter by others. Even this latter one (McCaw et al.2001, J Am Anim Hosp Assoc. 37:356-363) concludes that "No significant differences in health status were seen in cats treated with protein A and/or Interferon alpha, but therapy with protein A results in the owners' subjective impression of improved health of their FeLV-infected cats". Subjective or not, I have the same impression: one of my cats, Pupa, initiated SPA therapy in the begganing of 2007, after a lymph node lymphoma has been diagnosed. Soon she recovers humor, appetite, and weight, the blood values turns normal and she achieves tumor remission for several weeks during SPA treatment; but the tumor returns latter and Pupa died in the end of the year, after the fourth session of a combined chemotherapy protocol (apparently due to the chemo side effects). Jorge, the survivor, is in a much better state today than he was two years ago, when tested FeLV+ in tree successive exams. Excuse me for any misunderstanding, English is not may native language. Have a Good Luck Hebert ________________________ > Felvtalk mailing list > Felvtalk@felineleukemia.org > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org _________________________________________________________________ Descubra todas as novidades do novo Internet Explorer 8 http://brasil.microsoft.com.br/IE8/mergulhe/?utm_source=MSN%3BHotmail&utm_medium=Tagline&utm_campaign=IE8 _______________________________________________ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
