Hello Freesurfer Experts!

I am encountering the dreaded mri_glmfit error:  matrix is ill-conditioned
or badly scaled, condno = 1e+08. I have tried to troubleshoot how to solve
this problem from other inquiries, however, I still have had no luck. I am
trying to run a 4 group 1 variable analysis: with diagnosis being my
variable of interest and trying to regress out the effects of sex and age.

  1. Command line:
    mri_glmfit --y lh.10.73.SZHC.mgh --fsgd g4v1.73.fsgd dods --C
SZ-HC.intercept.73.mtx --surf fsaverage lh --cortex --glmdir g4v1.73.lh
  2. The FSGD file (if using one) (see attached)
  3. And the design matrix:
           0.5 0.5 -0.5 -0.5 0 0 0 0 (or see attached)

To the best of my knowledge, all my files are the right format and I
believe I have adequate number of participants per group?
I also tried mean centering my age variable. I had success when I ran just
a two group analysis (diagnosis) not controlling for sex or age, however,
as soon as I try to run four groups, I encounter this error. I have no idea
how to proceed.

I am looking forward to your response!
Thanks,


Lindsay

-- 
Lindsay Hanford, BSc, PhD Candidate
McMaster Integrative Neuroscience Discovery & Study | *Department of
Psychology, Neuroscience & Behaviour *
McMaster University *|* 1280 Main Street West, PC329 Psychology Building *|*
 Hamilton, ON, L8S 4L8
905 525 9140 x24784 *|* [email protected]

Attachment: g4v1.73.fsgd
Description: Binary data

Attachment: SZ-HC.intercept.73.mtx
Description: Binary data

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