Hi Jonathan

as far as we know, FreeSurfer is the most reliable and robust 
longitudinal brain morphometry tool that is publicly available. We are 
working to improve it (always!), but the answer to your question is yes, 
certainly 5.3 and the upcoming 6.0 are both excellent longitudinal tools
Bruce


On Wed, 8 Jun 2016, Greenberg, Jonathan wrote:

> Hello Are the volume and thickness measures in FreeSurfer's aseg.stats and
> aparc.stats accurate and reliable enough to assess changes in volume and
> thickness longitudinally? I have heard there have been some
> accuracy/reliability issues in these files in older versions of FreeSurfer.
> Is the data in these files strong enough to base a publication on?
> Thanks!
> Jonathan
> 
>
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