It depends on what you are trying to do with the statistic. But at first 
glance, I would guess that it is not since the statistic (mean and 
stddev) will be a mixture of across subjects and time points. It will be 
hard to interpret

On 5/8/2020 2:22 PM, Nasiriavanaki, Zahra wrote:
> Hi Freesurfer experts
>
> I have extracted the time course of a task fMRI data in a specific contrast 
> and within a specific ROI, in 7 subjects.
> Consider my specific ROI has 1200 voxels and I extracted the time course for 
> a duration of 5 TRs. After extracting the timecourse, I have a matrix of 
> 1200x5 for each subject.
> To calculate the average timecourse, I concatenated the matrices for the 7 
> subjects and made one matrix of 8400x5. Then I averaged across columns which 
> gives me one mean per column. I also calculated the standard error for each 
> column.
> My question is if this voxel wise way of averaging and calculating the 
> standard error is statistically correct or not.
> I deeply appreciate any comments on this.
>
> Thanks a lot
> Mona
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