that is quite strange. Does it happen every time? What is the 
mri_glmfit-sim command line and terminal output?

On 11/23/2022 2:47 PM, Vicente Ferrer wrote:
>          External Email - Use Caution
>
> Dear Freesurfer users,
>
> I was trying yo use mri_glmfit-sim after using mri_glmfit that run 
> successfully and I encounter this error:
>   
>
> ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08
>
>
> --------------------------------
> -------- ERROR: READ THIS -----------------
> --vvvvvvvvvvvvvvvvvvvvvvvvvvvvvv-----
> Possible problem with experimental design:
> Check for duplicate entries and/or lack of range of
> continuous variables within a class.
> If you seek help with this problem, make sure to send:
>    1. Your command line:
>      mri_glmfit --C 
> /bcbl/home/public/PD_ANALYSIS/FREESURFER_PPMI/stats/lh.atr.avg16_syn_bbr.FA_Avg.corr_g_glmdir/tmp.mri_glmfit-sim-29440/contrast_moca_groups.mtx
>  --sim perm 1000 1.5 
> /bcbl/home/public/PD_ANALYSIS/FREESURFER_PPMI/stats/lh.atr.avg16_syn_b  
> br.FA_Avg.corr_g_glmdir/csd/perm.th15.abs.j001 --sim-sign abs --fwhm 0 --fsgd 
> /bcbl/home/public/PD_ANALYSIS/FREESURFER_PPMI/stats/lh.atr.avg16_syn_bbr.FA_Avg.corr_g_glmdir/y.fsgd
>  dods --mask /bcbl/home/public/PD_ANALYSIS/FREESURFER_PPMI/stats/lh.atr.avg  
> 16_syn_bbr.FA_Avg.corr_g_glmdir/mask.mgh --y 
> /bcbl/home/public/PD_ANALYSIS/FREESURFER_PPMI/stats/lh.atr.avg16_syn_bbr.FA_Avg.corr_g_glmdir/eres.mgh
>  --perm-force --seed 1669778971
>    2. The terminal output of this program (ie, everything it prints to the 
> screen)
>    3. The FSGD file 
> (/bcbl/home/public/PD_ANALYSIS/FREESURFER_PPMI/stats/lh.atr.avg16_syn_bbr.FA_Avg.corr_g_glmdir/y.fsgd)
>    4. The design matrix (null)/Xg.dat
> Attempting to diagnose further
> SumSq: Min=1.455099 (col 24), Max=8.657582 (col 23)
>   ... could not determine the cause of the problem
> --^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^----
>
> Seems like there is a problem with the condition matrix, but I do not 
> understand why. Could you help me with this problem? I attached the contrast 
> and fsgd files
>
> Best,
> Vicente Ferrer
> Predoctoral Researcher BCBL
> http://secure-web.cisco.com/1kWZEOu8GTFhJvEwUHVoEpHYRwVtjwPjaW-68jFXGIsKvsccvtZ_SpRT4mbfMn9yTEj2SS5sODMuPyTAI7wxqhCmRxBRJ-35S_I8dxkyBkn-mSO5ejNKj3y_fRHlzfZYF0Y7e4avfl65oYvF1P9f6zlpO9fvp61CMx3UMDUkUt33HANwhKrNAQrsy2Y5VCcoRrA2AKBS0Z5P-jUa88tp7dylA1Zd2jmD5f7dpneDGC1UTgcKCSiQESkTtkx8M29TK78bxICiS2DYkMxYTENKlkex0JPgoayYX8JXmUgwvPcKnzKLxI-NITvFv7ql7vHrpEha80-krYMT5O5ictU2HZA/http%3A%2F%2Fwww.bcbl.eu
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