I believe TweetDeck uses GAE as part of their solution.  Check out:
http://googleappengine.blogspot.com/2010/04/tweetdeck-and-google-app-engine-match.html

On Jan 25, 4:29 am, "Brandon Wirtz" <drak...@digerat.com> wrote:
> www.Xyhd.tv  It runs in a hybrid model with GAE...    The website earns
> high-5 figures a year.  Which more than pays for the writing staff, none of
> whom write full time.  We estimate we save about $500 a month on hosting by
> using GAE, and the speed that GAE likely improves our on-site
> adconversion/clickthrough by 20% which because of the nature of adwords
> auction system results in about 35% more adsense money.
>
> Which works out to use making about $30k more a year between the savings in
> hosting and the additional income from having a faster site.
>
> -Brandon Wirtz
> CEO BlackWaterOps.com
>
> -----Original Message-----
> From: google-appengine@googlegroups.com
>
> [mailto:google-appengine@googlegroups.com] On Behalf Of Ricardo1980
> Sent: Saturday, January 22, 2011 3:36 PM
> To: Google App Engine
> Subject: [google-appengine] Where can I find commercial successfully
> websites created using GAE?
>
> Hello all!
>
> Where can I find commercial successfully websites created using GAE?
> Is there any list available?
> Here I can see open source 
> projects:http://groups.google.com/group/google-appengine/web/google-app-engine...
> ource-projects
> But where commercial projects?
>
> Thanks a lot for your help.
>
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