.25 is the least effective round out there, but it's better than nothing.
As they say, a .25 in the hand beats a .45 back home in the safe. 
And in many cases, producing a firearm makes your attacker change his mind 
about his target selection. 

I'm more concerned with the safety of loose pocket carry than with the potency 
of your sidearm. You don't want us to start calling you Plaxico when you shoot 
yourself in the leg. Get a pocket holster, or at the very least, never, ever 
put anything else in the pocket with the gun. 
https://thefiringline.com/forums/showthread.php?t=497307


That said, there are two schools of thought on the matter:
Get the most powerful 50 grain FMJ you can find and hope it penetrates enough 
to do something, or use Hornady 35gr XTP hollow points to make a larger but 
shallower wound channel. 
https://www.glocktalk.com/threads/best-25acp-defense-ammo.1647567/

> On May 12, 2017 at 7:37 AM archer75--- via Mercedes <mercedes@okiebenz.com> 
> wrote: 
> I have a Bauer (formerly Remington) 25 cal semi-automatic pistol, and hollow 
> point (probably jacketed) rounds. Some police say this combination will stop 
> a housebreaker or mugger, others say it will just make them mad; that I 
> should get a bigger pistol and cartridge. All agree that a 12 ga will stop 
> them.
> I like the tiny little Bauer because I can stick it in my side pants pocket 
> and no one suspects it's there, and because I seldom feel the need for it and 
> leave it home.

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