I would also recommend looking into some 3rd party tools.

http://www.percona.com/docs/wiki/percona-xtrabackup:start - Backup Innodb, 
MyISAM and XtraDB engines.
http://www.maatkit.org/ - Packed with useful features inc a parallel 
dump/import.

There's some great features in both products. I will leave you to do your own 
research into the tools as knowing their features will benefit you.

Best wishes

Andy
________________________________________
From: ext Jay Ess [li...@netrogenic.com]
Sent: 20 April 2010 09:06
Cc: mysql@lists.mysql.com
Subject: Re: better way to backup 50 Gig db?

Gavin Towey wrote:
> What Shawn said is important.
>
> Better options:
> 1. Use InnoDB, and then you can make a consistent backup with `mysqldump 
> --single-transaction > backup.sql`  and keep your db server actively 
> responding to requests at the same time.
>
> 2. Use something like LVM to create filesytem snapshots which allow you to 
> backup your database, while only keeping a read lock on the db for a second 
> or so.
>
3. Set up replication and backup the replicated data using any of the
above method.



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