Nice clock!
In my circuit, the USB data lines are not connected to the MCU. Actually, I 
expect that the negotiation will be done by the FT230X (USB to basic UART 
IC), maybe I’m wrong. 
When plugged in, the device should only consume a few mA, I will delay 
powering on the nixies. For the HV, I use a flyback design with a LT3757 
that has a soft-start function, so I don’t expect spikes over 500mA. With 
the nixies and neons powered on, the device should not consume more than 
400 mA. That’s the theory…
I will follow your suggestion and use a hub for testing, thanks Jon.

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