I am not aware of any papers specifically addressing the half-live
issue, but there are tons of original papers and tutorials on TMDD, just
search the web
Thanks
Leonid
On 4/29/2021 9:48 AM, Niurys.CS wrote:
Dear Leonid,
Many thanks for clearing up my doubt. Can you suggest me any paper to go
into this topic in any depth.
Best,
Niurys
El 28/04/2021 19:34, "Leonid Gibiansky" <lgibian...@quantpharm.com
<mailto:lgibian...@quantpharm.com>> escribió:
There is no such thing as half-life of elimination for the nonlinear
drug. But one can compute something like half-life:
1. Half-life of the linear part (defined by CL, V1, V2, Q): this
defines the half-life at high doses/high concentrations when
nonlinear elimination is saturated.
2. Washout time: for the linear drug, 5 half-lives can be used to
define washout time. During this time, concentrations drop
approximately 2^5=32 times. So one can simulate the desired dosing
(single dose or steady state), find the time from Cmax to Cmax/32
and call it washout time (or time to Cmax/64 to be conservative)
Thanks
Leonid
On 4/28/2021 5:17 PM, Niurys.CS wrote:
Dear all
I need some help to assess the elimination half life of a
monoclonal antibody.
The model that describes the data is a QSS aproximation of TMDD
with Rmax constant. The model includes two binding process of
mAb to its target: in central and peripheral compartments.
Is there any specific equation to calcule lambda z and the
elimination half life for each of the TMDD aproximations?
Thanks
Niurys
