I am surprised by all the apologetic replies about mailing lists, when "Reply-To:" is in fact standardized for more than 30 years, and it has nothing to do with mailing lists.
Wietse Citing from RFC 5322 section 3.6.2 (published 2008): When the "Reply-To:" field is present, it indicates the address(es) to which the author of the message suggests that replies be sent. In the absence of the "Reply-To:" field, replies SHOULD by default be sent to the mailbox(es) specified in the "From:" field unless otherwise specified by the person composing the reply. Citing from rfc2822 section 3.6.2 (published 2001): The originator fields also provide the information required when replying to a message. When the "Reply-To:" field is present, it indicates the mailbox(es) to which the author of the message suggests that replies be sent. In the absence of the "Reply-To:" field, replies SHOULD by default be sent to the mailbox(es) specified in the "From:" field unless otherwise specified by the person composing the reply. Citing from RFC 822 section 4.4.4 (published 1982): o If the "Reply-To" field exists, then the reply should go to the addresses indicated in that field and not to the address(es) indicated in the "From" field.