The only downside I can think of is that you may not be able to friction shift 
over an 11-speed cassette well if the spacing is narrow.

Wonder what the weight savings balance is, though?
-1 silver shifter and pod
-1 cable
-1 ferrule
-1 housing
-1 front derailer/adapter
-1 to 2 chainrings
-1 lube for cable
-1/2 cable route under bb
-1 grease/beeswax for front silver shifter parts
+1.5 extra turn of bartape to push into vacant bar end hole.
+1 cork for the bar end
+3 bigger cassette cogs.
Looks like the 1x setup is lighter weight setup.

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