<https://lh3.googleusercontent.com/-LsPltaM-12E/VjNPjh2ChNI/AAAAAAAADZM/Kpcv1CELLjU/s1600/25percent.jpg> I retrofitted a Litespeed Blue Ridge with a Rohloff hub about 17 years ago - I think my hub serial number is in the 2000s. It's never given me any problems, and has been toured on extensively, including several trips in Europe. It's definitely noisier in most gears than a well-adjusted derailleur setup, and vibration can be felt in several gears as well, but I don't think the efficiency is much different. When I started with it I used the recommended 46t chainring and 16t cog, but before a two month tour in Switzerland I swapped to a 38t chainring, which turned out to be a good choice, as we went up quite a few climbs with gradients like this:
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