er, Robert; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com>
Subject: RE: [NMusers] SAEM and IMP
Thanks, Bob. This indeed has been an interesting and thought provoking
discussion.
I too took another look at this. I thought, without really doing any analysis,
that the directionality bias using
specified DF or
Cartesian product of p independent 1D t random variables with specified DF?
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Bauer, Robert
Sent: Thursday, May 15, 2014 9:57 PM
To: nmusers@globomaxnm.com
Subject: RE: [NMusers] SAEM and IMP
Bob
Bob:
Yes, when I was developing the code for using the Sobol method in NONMEM, I
too found that using the t-distribution with Sobol/Quasi normal method resulted
in biased assessments of the objective function, when I used the unmodified
standard technique of generating t-samples. So, I experim
owner-nmus...@globomaxnm.com] On Behalf Of
Bob Leary [bob.le...@certara.com]
Sent: 15 May 2014 19:22
To: Emmanuel Chigutsa; Pavel Belo; nmusers@globomaxnm.com
Subject: RE: [NMusers] SAEM and IMP
Hi Emmanuel,
While I am a strong advocate of using quasi-random rather than pseudo- random
sequences for importanc
that,
but it sounds interesting and might be worth a try.
From: Pavel Belo [mailto:non...@optonline.net]
Sent: Thursday, May 15, 2014 4:42 PM
To: Bob Leary
Cc: Emmanuel Chigutsa; nmusers@globomaxnm.com
Subject: RE: [NMusers] SAEM and IMP
Hello Bob,
If you can send a NONMEM $EST statement, which
ject: Re: [NMusers] SAEM and IMP
Hi Pavel
I have experienced a similar problem. In my case, the following code for
IMP after SAEM (using NM7.3) greatly reduced the Monte Carlo OFV noise
from variations of about +/- 60 points to variations of +/- 6 points
(though still not goo
hen use a 1-d pseudo-random sequence to generate the chi-square random
variable.
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Emmanuel Chigutsa
Sent: Thursday, May 15, 2014 1:03 PM
To: Pavel Belo; nmusers@globomaxnm.com
Subject: Re: [NMusers] SAEM and IMP
1:01 AM
>Subject: [NMusers] SAEM and IMP
>
>
>Hello NONMEM Users,
>
>As SAEM does not provide a useful objective function, the manuals
>recommend using IMP after SAEM. It works well in many cases when IMP
>works well. When IMP works well, SAEM is not always needed. SAE
Behalf Of Pavel Belo
Sent: Thursday, May 15, 2014 11:02 AM
To: nmusers@globomaxnm.com
Subject: [NMusers] SAEM and IMP
Hello NONMEM Users,
As SAEM does not provide a useful objective function, the manuals recommend
using IMP after SAEM. It works well in many cases when IMP works well. When
IMP
nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Pavel Belo
Sent: Thursday, May 15, 2014 11:02 AM
To: nmusers@globomaxnm.com
Subject: [NMusers] SAEM and IMP
Hello NONMEM Users,
As SAEM does not provide a useful objective function, the manuals recommend
using IMP after SAEM. It w
Hello NONMEM Users,
As SAEM does not provide a useful objective function, the manuals
recommend using IMP after SAEM. It works well in many cases when IMP
works well. When IMP works well, SAEM is not always needed. SAEM is
really needed when the other methods do not work well.
The issue i
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