Glycerin and other humectants have been shown to act as transdermal penetration enhancers. Some possible alternates for glycerin are glyceryl triacetate, sorbitol, polyethylene glycol, propylene glycol, polysaccharides (such as fructose, glucose, maltose, etc.), corn syrup, polyols, urea and derivatives and natural honey.
See references below. - Steve N http://www.informaworld.com/smpp/content~db=all~content=a777711685 Moisturizing Lotions can Increase Transdermal Absorption of the Herbicide 2,4-Dichlorophenoxacetic Acid Across Hairless Mouse Skin " Moisturizing lotions can be an effective treatment for occupationally induced dry skin. These compounds are designed to be hygroscopic and retain water to keep the stratum corneum hydrated, while at the same time enhancing the horny layer to prevent increases in transepidermal water loss (TEWL). Skin hydration levels, however, are known to influence barrier properties. The purpose of this work was to compare skin moisture levels induced by four commercially available moisturizing lotions with their capacity as transdermal penetration enhancers using the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) as a model chemical. Further, the effect of moisturizing the skin after washing with sodium lauryl sulfate (SLS) on transdermal absorption was determined. Skin moisture levels were also measured noninvasively and were correlated to penetration enhancement. Hairless mouse skin was pretreated with commercially available moisturizing lotions either with or without SLS washing and in vitro permeability studies were performed with the herbicide 2,4-D. The data demonstrate that pretreatment with three of the four lotions tested increased the transdermal absorption of 2,4-D as evidenced by cumulative penetration or faster lag times (p < 0.05). Skin moisture levels correlated with the penetration enhancement capabilities of the lotion. Washing the skin with 5% SDS increased the transdermal absorption of 2,4-D (p < 0.05) and application of moisturizing lotions increased the absorption further. In summary moisturizing lotions may influence transdermal penetration of the skin, with the more effective moisturizers having a greater effect on 2,4-D absorption." http://www.patentstorm.us/patents/4950475/description.html Novel film-forming gels with high concentrations of humectants and emollients " Examples of humectants useful in this invention include glycerine, sorbitol, polyethylene glycol, propylene glycol, polysaccharides (such as fructose, glucose, maltose, etc.), corn syrup, polyols, urea and derivatives and natural honey. Preferred humectants are propylene glycol and glycerine." http://www.faqs.org/patents/app/20080286349 SYSTEMS, DEVICES, AND METHODS FOR PASSIVE TRANSDERMAL DELIVERY OF ACTIVE AGENTS TO A BIOLOGICAL INTERFACE " The passive transdermal delivery device of claim 14 further comprising one or more humectants selected from urea, glycerine, propylene glycol, glyceryl triacetate, and polyols." From: needling around [mailto:ptf2...@bellsouth.net] Sent: Monday, July 05, 2010 1:46 PM To: silver-list@eskimo.com Subject: EXTERNAL:Re: CS>2 items ( skin problems--Thanks to Brooks Bradley & Mike Thanks Lois, Unfortunately I am sensitive to glycerin. Any thoughts? I will check for Brooks skin recipe! PT -- The Silver List is a moderated forum for discussing Colloidal Silver. Rules and Instructions: http://www.silverlist.org Unsubscribe: <mailto:silver-list-requ...@eskimo.com?subject=unsubscribe> Archives: http://www.mail-archive.com/silver-list@eskimo.com/maillist.html Off-Topic discussions: <mailto:silver-off-topic-l...@eskimo.com> List Owner: Mike Devour <mailto:mdev...@eskimo.com>
