At 4 oz a day, you are at the max daily amount I would take for 10 ppm CS. Personally, at that amount I would use the selenomethionine form of selenium. Do you know that the selenium you are taking is not selenomethionine?
Taking the selenium at a different time helps in that it prevents the selenium from complexing with the silver in the digestive tract. If they did complex in the digestive tract, the selenium/silver complex would just pass on out in the feces. But the amount of CS you are taking (at 10 ppm) is around the maximum amount the liver can excrete in a day. (I know about the Altman study that indicates that most of the silver in EIS is excreted by the kidney. But the info is misleading if you do not really understand EIS in vivo and how different forms of silver are excreted by the body. But it is somewhat complex and I do not want to get into that here.) So the chances of selenium and silver complexing is significant and I would use selenomethionine to avoid it. Just FYI, I personally only supplement with selenomethionine. Many forms of selenium complexes with silver but selenomethionine is the only form I have study data on that indicates it does not complex with silver. Below I provide some info on selenium and silver. - Steve N Hepatobiliary transport and organ distribution of silver in the rat as influenced by selenite. http://www.ncbi.nlm.nih.gov/pubmed/7292506 "Bile from rats injected with 110mAgNO3 (1 micromol/kg) were fractionated on Sephadex G-15 revealing binding of silver to one high molecular weight substance and one low molecular weight substance eluting corresponding to the void volume and glutathione (GSH) respectively. Fractionation of AgNO3 and GSH mixed in vitro gave rise to a polynuclear complex and a 1 : 1 complex of Ag+-GSH which both eluted corresponding to silver in bile. Depletion of GSH in the liver by diethylmaleate (3.9 mmol/kg) caused a parallel decrease in the biliary excretion of both silver and reduced GSH. These findings support the hypothesis that silver is excreted into bile by a GSH-dependent mechanism most likely using GSH as a carrier molecule. Selenite (1 micromol/kg) inhibited the biliary excretion of silver while AgNO3 (1 mumol/kg) did not influence the excretion of selenium into bile. Pretreatment with selenite (1 micromol/kg) also caused a retention of silver (AgNO3, 1 micromol/kg) in the blood, kidney and brain. The liver content of silver was decreased and the organ to plasma ratio of silver was unchanged for erythrocytes, but decreased for the brain, kidney and liver, respectively. The effects caused by selenite are attributed to the formation of Ag2Se complexes which are nearly water insoluble and probably unavailable for biliary excretion. Selenium metabolites (GSSeSG, GSSeH) which are excreted into bile are probably not available for complexing with Ag+." [I will try and simplify the text above: 1. Silver (in solution) is excreted in the bile by using glutathione (GSH) as a carrier molecule. 2. Selenite, a form of selenium, inhibits the excretion of silver while silver does not influence the excretion of selenium into bile. 3. Selenite causes the retention of silver in the blood, kidney and brain. 4. The effects above are caused by silver-selenium complexes that are nearly water insoluble and probably unavailable for biliary excretion. 5. Ergo, selenium reduces the excretion of silver and causes retention in the blood and tissues.] Toxicological Profile for Silver http://www.atsdr.cdc.gov/toxprofiles/tp146-c2.pdf "The deposition of silver in the kidney was increased under conditions of high selenium exposure. This may be important in the development of argyria in people exposed to silver who ingest foods that contain large amounts of selenium." "It should be noted that selenium plays a dual role in the toxicity of silver. On the one hand, it increases the silver deposition rate in body tissues, which suggests that humans exposed to both high selenium and high silver may be more likely to develop argyria. On the other hand, a Selenium deficient diet combined with high silver intake can cause liver necrosis." As I mentioned, the selenomethionine form of selenium does not cause an accumulation of silver in the tissues and still provides the necessary support of the liver. That is documented in the following study: Agricultural and Biological Chemistry, Vol.47 Bioavailability of Selenite, Selenomethionine and Selenocystine in Rats with Silver Loading To view study select the full text abstract at: http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal =bbb1961&cdvol=47&noissue=4&startpage=807 "Nevertheless, selenomethionine was the most effective for synthesis of glutathione perioxidase in the rat liver with silver. This is presumably because selenomethionine would be hard to combine with accumulating silver in the liver unless metabolized." Silver in solution is excreted in the bile by using glutathione (GSH) as a carrier molecule. And the study determined that selenomethionine provides for synthesis of glutathione without combining with silver. Small silver particulate is excreted by the kidney. There are more studies/articles but I think these cover it well enough. -----Original Message----- From: needling around [mailto:[email protected]] Sent: Thursday, August 26, 2010 6:46 PM To: [email protected] Subject: EXTERNAL:Re: Re:CS>My first post Hi Steve, Is there a dosage level of CS that requires the change to selenomethionine instead of selenium? I take selenium once a day in the evening and am wondering if I need to change the formulation. I take approximately 2 oz CS am and pm. If the CS is taken hours away from the selenium does that help? Thank you. PT -- The Silver List is a moderated forum for discussing Colloidal Silver. Rules and Instructions: http://www.silverlist.org Unsubscribe: <mailto:[email protected]?subject=unsubscribe> Archives: http://www.mail-archive.com/[email protected]/maillist.html Off-Topic discussions: <mailto:[email protected]> List Owner: Mike Devour <mailto:[email protected]>
