___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Argyria NOEL: None 3 1 5E-3
mg/kg/day
2- to 9-Year LOAEL: 1 g (total dose);
Human i.v. Study converted to an oral
dose of 0.014 mg/kg/day
Gaul and Staud, 1935
According to that.....
The RFD is 5 milligrams per kilo per day [mg, not ug] over a period of 70 years.
Note how they say that silver arsphenamine is "colloidal silver" [ode]
4.8 mg is below that level.
Now, just how many people have mistranslated Mg as Ug, thinking that the M stands for micro?
Everything I've seen that stated 'micro', had the word written out rather than being the symbol. [ode]
http://www.happyherbalist.com/fda_report.htm#reference%20dose
Quoting from Alexander G. Schauss, Ph.D. (John Hopkins University)
you should be advised that we recently completed an extensive review of the scientific literature on the safety of silver, especially as it relates to its one known potential side effect, namely, Argyria. Argyia is an irreversible discoloration of the pigment (skin) caused by excessive silver intake or chronic exposure to silver by certain tissues. The amount of silver required to develop Argyria is estimated to be 3.8 grams per day. By comparison standard 10 ppm colloidal silver contains silver in amounts equaling less than 1 milligram of silver (1,000 micrograms = 1 milligram; 1,000 milligrams - 1 gram), which therefore represents an amount approximately 1/500th to 1/1000th of the amount of silver considered to be a risk in the development of Argyria.
..seems to be some discrepencies and confusions out there about exactly what various people are trying to say about what...but all of it falls well below an average EIS users average daily consumption rate.
Ode
At 05:23 AM 7/6/2005 -0700, you wrote:
>>>>
frank? anybody?<<<<
nobody seemed to react to these statements posted here. excpet me, that is !
did you all miss it or are you just tired of dealing with it?
i'm very concerned by it because the quantities identified by the epa (not that i hold them in higher esteem than the skunk in my yard !) and my daily consumption converted from 20ppms/8oz to mg are like 1500% different !
hard for me to imagine that the epa could really be that much off !
and i'm thinking that maybe the conversion equasion was wrong.
could somebody help please?
below is my original post....
thanks,
angel
----- Original Message -----
From: <mailto:[email protected]>angel nest
To: <mailto:[email protected]>[email protected]
Sent: Sunday, July 03, 2005 7:50 PM
Subject: Re: silver toxicity / Frank again
But Frank... I think I might be in trouble....
What about this statement in one of Michael's emails...
>>>The US-EPA publishes an oral reference dose (RfD) that
is based on a threshold for certain toxic effects such
as cellular necrosis. In units of micrograms per kg
per day and is an estimate of the maximum amount of
daily silver exposure that is not associated with any
deleterious effects over a lifetime. Current RfD for
oral silver exposure is 5 micrograms per kg per day.
An average (european) 70 kg man: = 350 µg/day>>>
That means that my 4.8mg-4800mcg daily is about 1500% more than the safe daily dose !! I'm about 50kg ~105lbs, so I should only be consuming 250mcg, right ???
Or am I missing something ???
Thanks again,
Angel
From: <mailto:[email protected]>FRANK CUNS-RIAL
Angel
To convert part per million (by weight) into miligrams in 8 oz. do the following:
One fluid oz.of CS equals about 30 grams.
8 oz. of CS is therefore 240 grams in which you have 20 ppm.
The grams of silver contained in your 8 oz,
20x240/1000000=0.0048 gr or 4.8 miligrams.
This asumes that the specific gravity of a ppm CS dispersion is 1.00.
Hope it hels
Frank Cuns-Ria
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