GameRunner does make a good point. Most people run WINE so they can get a
program limited to Windows running on their GNU/Linux machine. The majority
of the time it is a non-free video game or program like Microsoft Office.
If you have the intention to run a free software/open source program designed
for Windows, there's probably a version for GNU/Linux out there already.
In a way it reminds me of emulators. The program to do the emulation is free,
but has the intention of running non-free programs. Sure, you can run
homebrew games on your emulator, but 99% of the time it is used to emulate a
proprietary game from the past via a ROM dump.