>>
But I have in the past I have received workbooks from clients, where Excel
will not open the attachment.
>>

I have as well. But that doesn't mean it's because Excel was open or that OE 
sent the file off the disk, assuming the sender used OE.

>> 
I know that those clients keep the large workbooks open on their desktop
continually throughout the day, and when they alter something they didn't mean 
to, or shouldn't - and the stuff in them is no longer presented as they want, 
or doesn't
balance: Then they ship the thing to me to have it 'put right' and returned.

<snip>

Having tried the removed file and pulled cable - then the only other things
are:

A large complex file - kept open and being changed (saved) during the
attach,
and on through the transmit -
and that will be fun to get timed right on a fast comms connection.

And the effect of AV processing on outward bound mail
- especially if it's set to remove the virus, and allow processing to
continue with the 'cleaned file'

Also - I suppose we shouldn't discount basic transmission errors -
>>

Any file can become corrupt when sent - usually it's because something screwed 
up during transmission and the file ended up munged. Two causes I am aware of 
are virus scanning and loss of TNEF data (affects mail sent using Outlook only).

If a program has a lock on a file it's more likely the email client will be 
unable to send it and display an alert, rather than send a corrupt copy. A few 
programs might hook into the document on the hard drive and attach it went sent 
from the client - but OE is not one of them. (Pegasus and Eudora would be more 
likely to do this since they store attachments in a folder on the drive, 
although I don't know that they do. One of the guys who uses those programs 
would.) 

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