I see, thanks for the quick clarification. So in the Method 2 there is a
chance that some voxels will show up in multiple ROIs, right? Is there a
modification of Method 2 that maximizes that number of labeled voxels while
ensuring that they will not show up in multiple ROIs?

Thanks again,
Tim


On Fri, Aug 20, 2010 at 4:15 PM, Douglas N Greve
<gr...@nmr.mgh.harvard.edu>wrote:

> The difference is the partial volume correction is different if there are a
> bunch of other labels there (aparc+aseg) vs only one label
>
> doug
>
> Timothy Vickery wrote:
>
>> Hi all,
>>
>> I'm creating binary mask volumes in a subject's native functional space
>> from the segmented brain in aparc+aseg.mgz (FS v 4.5). I have found that
>> doing this two different ways produces different results, and I'm wondering
>> if anyone can illuminate why this might occur and which method is more
>> appropriate (or what other method you would suggest)...
>>
>> Method 1: Resample aparc+aseg.mgz into native functional space using
>> mri_label2vol --seg aparc_aseg.mgz --fillthresh 0.5 [...plus the rest of
>> the appropriate inputs such as subject's bold/register.dat]
>>
>> Then I just parse the resulting image (using matlab or python code) into
>> separate binary masks for each unique identifier that I'm using...E.g., for
>> right IPL I load this image and create a new volume [newVol =
>> (oldVol==2008)] and save that out.
>>
>> Method 2: Create a label file from aparc+aseg.mgz for each unique
>> identifier that I'm using, and then use mri_label2vol to produce a binary
>> mask in native functional space:
>> mri_cor2label --i aparc+aseg.mgz --id 2008 --l rIPL.label
>> mri_label2vol --label rIPL.label --fillthresh 0.5 [... plus the rest of
>> the required inputs, same as those used in Method 1]
>>
>> Even though these seem like they should be equivalent to me, and although
>> the masks produced agree for the most part, I generally get several more
>> voxels per ROI using Method 2 than I do using Method 1 (and not complete
>> overlap otherwise). For instance, for one subject, Method 1 yields 308
>> voxels in rIPL, but Method 2 yields 316 voxels; disagreement between the two
>> occurs in a total of 26 of those voxels, so it isn't just a matter of Method
>> 2 being more generous. The discrepancy seems to be proportional to the size
>> of the ROI, so I get just a handful of disagreements for smaller ROIs (but
>> it seems to happen almost all the time).
>> Thanks for any advice on which method is better, or a suggestion of a
>> better method.
>>
>> Best,
>> Tim
>> ------------------------------------------------------------------------
>>
>> _______________________________________________
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>> Freesurfer@nmr.mgh.harvard.edu
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>>
>
> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358 Fax: 617-726-7422
>
> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html
>
>
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