Hi Panos, are you asking whether theunbalanced design will leadto one 
slope being different than another just because the numbers are 
different? That is not a problem. You can simply follow the instructions 
on the wiki.
doug



On 05/31/2013 11:26 AM, Fotiadis, Panagiotis wrote:
> Hey Doug,
>
> Sorry for the overwhelming amount of questions. I wanted to confirm 
> something. Suppose you want to do group analysis between two groups say a 
> healthy cohort vs a diseased cohort. Each cohort has ~40 and ~30 subjects 
> each (different people), and you want to compare how for instance the 
> cortical thickness decreases over age in the one group versus the other. Do 
> you still set the contrast vector as [0 0 1 -1]  ([intercept 1 intercept 2 
> slope 1 slope 2]) and follow the analysis described in 
> https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/GroupAnalysis or do you 
> go on a different way since there are different subjects instead of one with 
> 40 (or 30) different longitudinal data for each cohort? Don't we need to 
> correct the age slopes for the fact that we have 40 (and 30) different 
> subjects in each cohort?
>
> Thanks,
> Panos
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>

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Douglas N. Greve, Ph.D.
MGH-NMR Center
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