Dear Freesurfer team,

This may sound like a bit of a small question, but I could not find any exact 
answer elsewhere.

Does the exact orientation of the input image have much effect on the accuracy 
of the segmentation in Freesurfer?
It seems that some people apply ACPC alignment to the output of Freesurfer, so 
I am confused as to which order would be optimal.


Thank you in advance,
Kristine
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