Hi Kristine

no, it doesn't. Randy Buckner did a small study on this and found no 
detectable effect

cheers
Bruce
On Tue, 28 Feb 2017, Lee Subin Kristine wrote:

> Dear Freesurfer team,
> This may sound like a bit of a small question, but I could not find any
> exact answer elsewhere.
> 
> Does the exact orientation of the input image have much effect on the
> accuracy of the segmentation in Freesurfer?
> It seems that some people apply ACPC alignment to the output of Freesurfer,
> so I am confused as to which order would be optimal.
> 
> 
> Thank you in advance,
> Kristine
> 
>
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