>>But in the case where --psf 0 --no-tfe are specified, isn't the high 
resolution of gtmseg lost when rescaling intensities to mean reference 
region ?
Yes


On 2/14/19 5:25 PM, Matthieu Vanhoutte wrote:
>
>         External Email - Use Caution
>
>
>
> Le jeu. 14 févr. 2019 à 21:36, Greve, Douglas N.,Ph.D. 
> <dgr...@mgh.harvard.edu <mailto:dgr...@mgh.harvard.edu>> a écrit :
>
>
>
>     On 2/14/19 2:25 PM, Matthieu Vanhoutte wrote:
>     >          External Email - Use Caution
>     >
>     >> Le 14 févr. 2019 à 19:37, Greve, Douglas N.,Ph.D.
>     <dgr...@mgh.harvard.edu <mailto:dgr...@mgh.harvard.edu>> a écrit :
>     >>
>     >>
>     >>
>     >> On 2/14/19 1:14 PM, Matthieu Vanhoutte wrote:
>     >>>          External Email - Use Caution
>     >>>
>     >>>
>     >>>
>     >>> Le jeu. 14 févr. 2019 à 18:31, Greve, Douglas N.,Ph.D.
>     >>> <dgr...@mgh.harvard.edu <mailto:dgr...@mgh.harvard.edu>
>     <mailto:dgr...@mgh.harvard.edu <mailto:dgr...@mgh.harvard.edu>>> a
>     écrit :
>     >>>
>     >>>
>     >>>
>     >>>     On 2/14/19 12:16 PM, Matthieu VANHOUTTE wrote:
>     >>>>            External Email - Use Caution
>     >>>>
>     >>>> Hi Douglas,
>     >>>>
>     >>>> So to register PET to gtmseg space mri_gtmpvc command use nearest
>     >>>> neighbor, interpolation right ?
>     >>>     It does not map the PET to the gtmseg space. It maps the
>     gtmseg to
>     >>>     the
>     >>>     PET space. Since this is a segmentation, it uses nearest
>     neighbor.
>     >>>     But
>     >>>     the algorithm is much more complicated; see the paper.
>     >>>
>     >>>
>     >>> Thank you I will look into the paper, I was wondering how not
>     to loose
>     >>> the gtmseg resolution ?
>     >> I thought you wanted to turn off all PVC? If you want to
>     correct for the
>     >> tissue fraction effect, then don't use --no-tfe
>     > Oh, I had to miss something. I didn’t know PVC had several
>     components, whose one is tissue fraction effect… What are the
>     different corrections applied during PVC ?
>     Tissue fraction effect and correction for blur induced by the low res
>     nature of pet. See the paper.
>     > When papers mention no PVC they principally don’t correct for
>     tissue fraction effect ?
>     I don't know. Generally, people don't give many details on their
>     method.
>     >
>     > I wanted to know what is the interest of computing a high
>     resolution segmentation (gtmseg) if it goes to PET space and
>     resliced to its lower resolution ?
>     As I said before, this is not what happens. PETsurfer takes the
>     TFE into
>     account.
>     Please see the paper for how it is done.
>
>
> But in the case where --psf 0 --no-tfe are specified, isn't the high 
> resolution of gtmseg lost when rescaling intensities to mean reference 
> region ?
>
>     >
>     >>> Concerning RBV PVC in which order and what type of
>     interpolation are
>     >>> used since PVE corrected output is on gtmseg_space ?
>     >> This question does not make sense in the context of RBV. Each
>     ROI gets a
>     >> value, and this value is then assigned to all the voxels in
>     that ROI in
>     >> gtmseg prior to apply the RBV algorithm.
>     > Ok thank you, so in RBV case native PET is interpolated
>     (trilinear?) first to gtmseg space ?
>     >
>     >>>> And what about the interpolation method to use when
>     projecting PVE
>     >>>> corrected PET on surface  ?
>     >>>     I usually use nearest neighbor to avoid interpolation
>     >>>
>     >>>
>     >>> Should you precise this on PETSurfer wiki since on the
>     mri_vol2surf
>     >>> command trilinear interpolation is used by default ?
>     >> By default, mri_vol2surf uses nearest neighbor. mri_vol2vol
>     uses trilin
>     >> by default. An unfortunate inconsistency I made about 15 years
>     ago and
>     >> have been too afraid to change it:)
>     > Thank you I didn’t know this one and supposed the trilinear as
>     default as it is done in moi_vol2vol. Good to know it :)
>     >
>     >>> Best.
>     >>>
>     >>>> Thanks,
>     >>>>
>     >>>> Matthieu
>     >>>>
>     >>>> On 14/02/2019 17:44, Greve, Douglas N.,Ph.D. wrote:
>     >>>>> The GTM operates on regions, so you can't do trilin interp. The
>     >>>>> operations that you describe below are not used in mri_gtmpvc.
>     >>>     If  you
>     >>>>> are trying to get something close to what the GTM does, then
>     >>>     use nearest
>     >>>>> neighbor
>     >>>>>
>     >>>>> On 2/14/19 3:43 AM, Matthieu Vanhoutte wrote:
>     >>>>>>              External Email - Use Caution
>     >>>>>>
>     >>>>>> Hi Douglas,
>     >>>>>>
>     >>>>>> Could you help me concerning my previous questions ?
>     >>>>>>
>     >>>>>> Thanks,
>     >>>>>> Matthieu
>     >>>>>>
>     >>>>>>> Le 11 févr. 2019 à 17:37, Matthieu VANHOUTTE
>     >>>     <matthieuvanhou...@gmail.com
>     <mailto:matthieuvanhou...@gmail.com>
>     <mailto:matthieuvanhou...@gmail.com
>     <mailto:matthieuvanhou...@gmail.com>>>
>     >>>     a écrit :
>     >>>>>>> Hi Douglas,
>     >>>>>>>
>     >>>>>>> Thanks for clarification. Why use "nearest neighbor" instead
>     >>>     of classical "trilinear" interpolation ?
>     >>>>>>> Should it be done as well when projecting from volume to
>     >>>     surface with mri_vol2surf ?
>     >>>>>>> Best,
>     >>>>>>>
>     >>>>>>> Matthieu
>     >>>>>>>
>     >>>>>>> On 11/02/2019 17:32, Greve, Douglas N.,Ph.D. wrote:
>     >>>>>>>> It will not used trilinear interp. Try it with nearest
>     neighbor
>     >>>>>>>>
>     >>>>>>>> On 2/10/19 11:55 AM, Matthieu Vanhoutte wrote:
>     >>>>>>>>>  External Email - Use Caution
>     >>>>>>>>>
>     >>>>>>>>> Dear Douglas,
>     >>>>>>>>>
>     >>>>>>>>> Before using "mri_gtmpvc --psf 0 --no-tfe -- rbv" according
>     >>>     your advice to obtain voxel-wise output rescaled without PVC
>     >>>     correction, I have done sequentially the different steps
>     to obtain
>     >>>     this output. However, when comparing voxel-wise rescaled
>     output
>     >>>     (rbv.nii.gz) between the two methods, final values at each
>     voxel
>     >>>     are not the same…
>     >>>>>>>>> To obtain first rescaled voxel-wise output I have used
>     >>>     sequentially these steps:
>     >>>>>>>>> 1.       Concatenate transforms from PET space to gtmseg.mgz
>     >>>>>>>>> 2.       Register native PET into gtmseg space (trilin.
>     >>>     interpolation)
>     >>>>>>>>> 3.       Compute mean PET inside reference regions (with
>     >>>     regions masks from gtmseg.mgz)
>     >>>>>>>>> 4.       Compute intensity normalized PET images in gtmseg
>     >>>     space
>     >>>>>>>>> Doesn’t the "mri_gtmpvc --psf 0 --no-tfe -- rdv" command
>     >>>     use these same steps ?
>     >>>>>>>>> Best,
>     >>>>>>>>> Matthieu
>     >>>>>>>>>
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