We generally do not normalize it by anything. ICV norm is not needed
because thickness does not scale with head size. Sometimes people will
normalize by mean thickness, but that changes the question being
answered, so that is more a question for you
On 6/24/2021 3:01 PM, Gabbo Ramírez García wrote:
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Hi freesurfer user.
I have been working with some cortical thickness values of a control
group to test some changes related to cognitive training. However, I
have been hesitating about whether I have to normalize the cortical
thickness values (as happens with subcortical volumes and ICV) or not.
I have read a little about it and I understood that I could use the
ICV or/and mean cortical thickness, but I didn't find a specific
criteria to do or not this normalization. Any clue, recommendation,
explanation or paper about this will be very helpful.
Thanks in advance.
*or reposting discussion of this question.
*Gabriel R.*
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