http://xkcd.org/829/

On Thu, Dec 2, 2010 at 11:59 PM, Miles Parker <milespar...@gmail.com> wrote:

> Yeah -- staying out of the name the pill controversy ;) -- one neat little
> tidbit in the "I'm always amazed by how little I know and how little I've
> thought about what I do know" category. We think of Arsenic as a poison, but
> the only reason we think of it as a "poison" is (duh) that it is bad for
> *us*, i.e. humans + every other critter that we've run into before now. But
> the reason that it is bad is not that it is different from our chemistry,
> like an acid, but that it is so close to our chemistry, being next to
> phosphorous on the old periodic table, thus disrupting cellular mechanisms.
> So while typically we think of things that are close in structure or design
> to be friendly in fact here a movement to our nearest neighbor represents a
> major boundary shift, while one to a distant neighbor would of course be
> quite unlikely as the chances of slotting into the same role would be very
> slim. That idea could certainly argue for the idea that the current six
> element setup is arbitrary against some set of possible configurations. Once
> a choice is made in that configuration space it would be very unlikely (and
> only under these kind of extreme conditions) that we would move off it. The
> fact that we can (hmm, I mean I actually probably can't so please don't
> subject me to any experiments) anyway makes the argument that "because
> that's the only way it works here" even more tenuous.
>
>
> On Dec 2, 2010, at 9:21 PM, ERIC P. CHARLES wrote:
>
> Following Glen, Roger, and James, and also wondering why Nick is being a
> pill....
>
> I believe the report is of interest for showing an organism that uses
> arsenic in interesting ways, but it gets its magical-shininess (i.e. Science
> worthiness) for showing an organism that does not use phosphorous. We have
> never found a life form that could do the "life" thing without phosphorous. It
> is almost (almost) like finding an organism that uses silicon instead of
> carbon.
>
> Oh, and then there is the potential for practical application... like
> cleaning up arsenic, which is a common pollutant coming out of mines. But
> anything like that is a long way off.
>
> Eric
>
>
> On Thu, Dec 2, 2010 08:03 PM, *Roger Critchlow <r...@elf.org>* wrote:
>
>
>
> On Thu, Dec 2, 2010 at 4:39 PM, glen e. p. ropella 
> <g...@tempusdictum.com>wrote:
>>
>>
>> [*] FWIW, I find it odd for you to ask, of this particular article, "why
>> is this important?"  Of all the obscure, mumbo-jumbo journal articles
>> out there (our discussion of PoMo aside ;-), it seems blatantly obvious
>> to me that the substitution of As for P in DNA is important, even if we
>> don't know what the implications are.  I am woefully ignorant of the
>> literature, though.  Is it fairly common to find and report substitutes
>> for DNA components?
>>
>>  No, it's not common, it's never been reported before, all DNA and RNA in
> life as we have known it up until today has been based on phospho-esters.
>
> -- rec --
>
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> Eric Charles
>
> Professional Student and
> Assistant Professor of Psychology
> Penn State University
> Altoona, PA 16601
>
>
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>
>
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> Meets Fridays 9a-11:30 at cafe at St. John's College
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