Dear Sir/Madam: I have been trying to identify a CpG island sequence in the promoter of the TCF4 gene in the human and rhesus. From the genome browser I was able to download a small CpG island sequence of about 291 bases long with ~30-32 CpG dinucleotides in the human and macaque. However, I did find a paper published last year looking at CpG methylation of the TCF4 promoter sequence in gastric carcinoma patients and where the authors had identified a CpG island sequence immmediately upstream of the transcription start site and have their enitre study on this sequence. However, I was surprised to find this CpG sequence missing in the genome browser sequence. I have attached a copy of the paper for your reference. I am wondering if you have strict criteria for defining a CpG island. Will look forward to hear your response. Thanks Mahehs
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