The easiest answer is to work it out. Do some simulations (without variability) with multiple subjects with identical PK parameters BUT different sampling times. Tabulate your AUCs and compare the results for different sampling times!
_____ From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Martin Bergstrand Sent: Friday, March 20, 2009 8:45 AM To: 'Ethan Wu'; nmusers@globomaxnm.com Subject: RE: [NMusers] calculation of AUC Dear Ethan, You need to provide more information on how you plan to calculate AUC otherwise the question can't be answered. It is of course possible to calculate the AUC without any influence of the sampling frequency. You should be able to find examples of how to do this in the NMusers archive. See for example the answer from Mats Karlsson in this thread (http://nonmem.org/nonmem/nm/98apr032002.html). Kind regards, Martin Bergstrand, MSc, PhD student ----------------------------------------------- Department of Pharmaceutical Biosciences, Uppsala University ----------------------------------------------- P.O. Box 591 SE-751 24 Uppsala Sweden ----------------------------------------------- <mailto:martin.bergstr...@farmbio.uu.se> martin.bergstr...@farmbio.uu.se ----------------------------------------------- Work: +46 18 471 4639 Mobile: +46 709 994 396 Fax: +46 18 471 4003 From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ethan Wu Sent: den 20 mars 2009 13:05 To: nmusers@globomaxnm.com Subject: [NMusers] calculation of AUC Hi all, to calculate AUC of one of the compartments using ADVAN6, if it is a fixed time interval, will the AUC be influenced by the frequncy of sampling of the dataset within this interval or not? thanks _____ No viruses found in this incoming message Scanned by iolo AntiVirus 1.5.6.4 http://www.iolo.com <http://www.iolo.com/iav/iavpop3>
