I have not configured autoreply, only the notification (in Notifications 
(Event) in the Admin menu) which the agent is not receiving.
(As far as I can remember, everything is at defaults from installer.pl script. 
I have just created Queues, one agent (me), System addresses and PostMaster 
Filter.) OTRS 3.1.12.

Here are the last few entries from OTRS Log (admin menu):

Fri Feb 22 13:50:02 2013           notice   OTRS-otrs.GenericAgent.pl-10 Run 
GenericAgent Job 'Tickets_to_NOTIFICATION_queue' from db.
Fri Feb 22 13:50:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31904)!
Fri Feb 22 13:45:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31904)!
Fri Feb 22 13:40:02 2013           notice   OTRS-otrs.GenericAgent.pl-10 Run 
GenericAgent Job 'Tickets_to_NOTIFICATION_queue' from db.
Fri Feb 22 13:40:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31904)!
Fri Feb 22 13:35:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31904)!
Fri Feb 22 13:30:02 2013           notice   OTRS-otrs.GenericAgent.pl-10 Run 
GenericAgent Job 'Tickets_to_NOTIFICATION_queue' from db.
Fri Feb 22 13:30:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31904)!
Fri Feb 22 13:25:01 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31904)!
Fri Feb 22 13:20:17 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  New Ticket [2013022210000144/TEST 3 - komple] created 
(TicketID=36,Queue=NOTIFICATION,Priority=3 normal,State=new)
Fri Feb 22 13:20:17 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Filter: 'zemanek' Stopped filter processing because of used 'StopAfterMatch' 
(Message-ID: 
<11b5df5a92b652418b8b6ecfdd2f5ca2ccdb5b9...@implmail.oksystem.impl>)
Fri Feb 22 13:20:17 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Filter: 'zemanek' Set param 'X-OTRS-Queue' to 'NOTIFICATION' (Message-ID: 
<11b5df5a92b652418b8b6ecfdd2f5ca2ccdb5b9...@implmail.oksystem.impl>)
Fri Feb 22 13:20:02 2013           notice   OTRS-otrs.GenericAgent.pl-10 Run 
GenericAgent Job 'Tickets_to_NOTIFICATION_queue' from db.
Fri Feb 22 13:20:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Removed PID (PostMasterMailbox/otrs/31592, because 1 hour old!
Fri Feb 22 13:15:01 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31592)!
Fri Feb 22 13:10:02 2013           notice   OTRS-otrs.GenericAgent.pl-10 Run 
GenericAgent Job 'Tickets_to_NOTIFICATION_queue' from db.
Fri Feb 22 13:10:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31592)!
Fri Feb 22 13:05:01 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31592)!
Fri Feb 22 13:00:02 2013           notice   OTRS-otrs.GenericAgent.pl-10 Run 
GenericAgent Job 'Tickets_to_NOTIFICATION_queue' from db.
Fri Feb 22 13:00:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31592)!
Fri Feb 22 12:55:02 2013           notice   OTRS-otrs.PostMasterMailbox.pl-10   
  Can't create PID PostMasterMailbox, because it's already running (otrs/31592)!

Regards
JZ

From: otrs-boun...@otrs.org [mailto:otrs-boun...@otrs.org] On Behalf Of Gerald 
Young
Sent: Friday, February 22, 2013 1:39 PM
To: User questions and discussions about OTRS.
Subject: Re: [otrs] Couldn't send mail: 550 5.7.1 Client does not have 
permissions to send as this sender

Is the autoreply arriving at the destination? If so, that's not the problem. 
It's the notification sent to the agent, which is addressed in OTRS Sysconfig. 
If the agent is receiving notifications, check the OTRS Log from the admin menu 
and provide context for the error.

On Fri, Feb 22, 2013 at 7:14 AM, Zemánek Jiří 
<zema...@oksystem.cz<mailto:zema...@oksystem.cz>> wrote:
Account used for authentication to SMTP server is this outsourcing@..... So it 
has the permission.

Regards
JZ

From: otrs-boun...@otrs.org<mailto:otrs-boun...@otrs.org> 
[mailto:otrs-boun...@otrs.org<mailto:otrs-boun...@otrs.org>] On Behalf Of 
Gerald Young
Sent: Friday, February 22, 2013 1:08 PM

To: User questions and discussions about OTRS.
Subject: Re: [otrs] Couldn't send mail: 550 5.7.1 Client does not have 
permissions to send as this sender

what account is being used for authentication to your SMTP server? Does this 
account have permissions to send as outsourcing@...?

On Fri, Feb 22, 2013 at 2:51 AM, Zemánek Jiří 
<zema...@oksystem.cz<mailto:zema...@oksystem.cz>> wrote:
Hello,

            unfortunatelly, there is no error. The the last entry in SMTP log 
(of Exchange server) is successfull authentication and that´s all.
Besides, the install script http://localhost/otrs/installer.pl found IMAPS and 
SMTPS is working fine....

Regards
JZ

From: otrs-boun...@otrs.org<mailto:otrs-boun...@otrs.org> 
[mailto:otrs-boun...@otrs.org<mailto:otrs-boun...@otrs.org>] On Behalf Of David 
Boyes
Sent: Thursday, February 21, 2013 5:36 PM

To: User questions and discussions about OTRS.
Subject: Re: [otrs] Couldn't send mail: 550 5.7.1 Client does not have 
permissions to send as this sender

That error is coming from the remote SMTP server. There should be a message 
logged on their side as to what address you are actually sending in the SMTP 
envelope and the address it's coming from. Contact your SMTP provider and ask 
them for that data and what IP ranges from which you are authorized to send. 
Are you using SPF records in your DNS? If so, then default config of modern 
versions of sendmail enforces SPF declared mail servers. I doubt that your new 
OTRS server is declared as a legitimate source of email if you're in early 
testing.

________________________________

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