FW: Re: [QUAD-L] D-Mannose

[William Willis]

My docs put me on mandelamine when I first got hurt back in 1971. It was a 
huge purple pill that I took 4 times a day. I took it for about 20 years 
until I got tired of the bother and expense. Haven't noticed much difference 
without it.


From: "Lori Michaelson" <[EMAIL PROTECTED]>
Reply-To: "Lori Michaelson" <[EMAIL PROTECTED]>
To: "Quad" <quad-list@eskimo.com>
Subject: Re: [QUAD-L] D-Mannose
Date: Wed, 20 Apr 2005 12:23:28 -0700
 I feel like I'm butting in here, Corie, but I hope my last lengthy email
wasn't too boring.  I've just HAD IT with UTIs.  And my last resort may be
to go back to irrigating daily with a vinegar/water solution.  I'm having
sludge again.  Not as bad as 6 yrs ago but still.
I, too, am going to look up Mandelamine
I had asked people if they kept track of WHAT TYPE OF BUG they had and 
WHEN.

Corie ... Why haven't you got a culture & sensitivity done yet since you're
symptomatic?  (remember to tell whomever takes your sample to the lab to
write "DO SENSITIVITIES REGARDLESS OF GROWTH")
Also, we've been out of touch privately for awhile (been one crisis after
another here for a year!).  Have you been having more urine problems of
late?  I have a slew of free cell minutes and would love to talk to you
again at a convenient time.
The thing that scares me the most is this article (below) on antibiodics &
D-Mannose, etc (I see I saved it in my notes on March 9th, 2003! But didn't
copy the source.  I'm sure it came up in my google search results) The
resistance to antibiodics is increasing and I had no REAL worries until I
got the bug Proteus (evil incarnate) AND Cipro doesn't do anything for me
anymore.
Note below in the article too that D-Mannose can be injected directly into
the bladder too.  But if it's not E-coli ... useless.
Best to find out what bug is in your urine before even trying Mannose or
Mandelamine.
"Urinary tract or bladder infection is both a painful condition and a major
cause of doctor visits. Every year 6 million Americans suffer at least one
occurrence of this common problem and 20% of this group experience more 
than
one episode. Antibiotics are routinely used for 10 days or longer to combat
the infection and provide relief.

Unfortunately, there is growing evidence that the sought after relief is
getting harder and harder to achieve for three very important reasons:
1. Only a few of the commonly used antibiotics achieve adequate levels in
the urinary tract to be fully effective; 2. The infection causing bacteria
attach to the mucosal wall of the bladder making removal difficult; and 3.
Infection causing bacteria are becoming increasingly resistant to
antibiotics. The third reason points out the growing concern that comes 
with
the use of antibiotics. Pathogenic bacteria are becoming resistant. Recent
data indicates that 20% of the patients admitted to a New York hospital are
resistant to standard antibiotic therapy. The problem is even greater in 
the
rest of the world, especially third world countries.

With respect to the first reason, there is little we can do to increase the
level of antibiotics in the urinary tract. The second reason, however,
offers the potential means to maintain urinary tract health and reduce the
ultimate use of antibiotics. It stands to reason that, if the bacteria
cannot attach to the mucosal wall of the bladder, they will pass from the
body in the urine and no infection will occur .We know that the most common
bacteria involved in urinary tract infections is E. coli. We also know that
E. coli is mannose sensitive.
How does this relate to maintaining urinary tract health? E. coli tend to
bind to the epithelial tissues on the interior surface of the bladder. This
ability of E. coli to bind to bladder tissue provides a home for subsequent
growth and infection. In the presence of Mannose, E. coli exhibits a 
greater
affinity for the Man- nose than the epithelial surface of the bladder. The
net result is that the E. coli either rapidly detaches from the bladder 
wall
and attaches to the Mannose or attaches to the Mannose before it can attach
to the bladder. The freely floating E. coli (attached to the Mannose) is 
now
readily eliminated on urination.

If the preceding is true, why hasn't Mannose been used routinely for
maintaining urinary tract health? Apparently, the reason for this can be
found in a single paper published on the use of Mannose in one patient. The
authors of this case report erroneously reported that Mannose was not 
orally
absorbed.

It was not until 1997 that Dr. Hudson Freeze published a clarifying paper
showing that Mannose is orally absorbed in both normal individuals and
patients with Carbohydrate Deficient Glycoprotein Syndrome. His work showed
that supplementation with Mannose increases blood levels in a dose 
dependent
manner. Peak blood levels are observed after 1-2 hours with a clearance
halftime of 4 hours. Clearance speed is critical to how quickly Mannose 
will
reach the bladder. No side effects were observed. Dr. Hudson concludes,
These results establish the feasibility of using Mannose as a potential
therapeutic dietary supplement."

What is Mannose/D-Mannose? It is a carbohydrate sugar with a molecular
weight of 180.16. Its low molecular weight and water solubility are keys to
its rapid absorption and excretion. Man- nose is naturally produced in the
body.
Supporting Evidence for the use of Mannose as a supplement to maintain and
support urinary tract health follows:
A. Adherence of E. coli was inhibited by Mannose [1. Med Microbiol1982 Aug
15 (3):303-16] B. A 10 % solution of Mannose injected directly into the
bladder significantly Reduced bacteriuria within I day ( efficacy is
dependent on concentration of Mannose & bacteria) [Urol Res
198311(2):97-102] C. Irrigation of the bladder with 6% Mannose inhibited
bacterial adherence: " As 6% Mannose effectively inhibited type 1 pili and
also had some antibacterial activity, it may reduce urinary tract infection
if used as irrigation solution." [Urol Res 1993 21 (6):401-5 U. of Basel
Switzerland- Urology Clinics, Gasser T.C.] D. P-fimbriated E. coli is the
most prevalent microorganism in acute un. ... P-fimbriated E. coli is
Mannose sensitive (readily attaches to Mannose). [J. Chemo- therapy 1999 
Oct
 (5):357-62] E. Mannose inhibition of the adherence of E. coli is dose
dependent. ...With the maximal inhibitory dose, adherence was reduced by
approximately 80%. (Invest. Urol. 1981 Mar: 18(5):364-70F] F. Mannose
inhibits E. coli adherence to urinary bladder epithelium. [Urol. Res. 1985
13(2):79-8 ] G. Mannose for Bladder and Kidney infections -Jonathan Wright 
M
D., Townsend Letter for Doctors & Patients, 1999 July p.96-98

Summary: Mannose, taken as directed, can help maintain a healthy urinary
tract by binding with infectious bacteria like E. coli before it can attach
to the bladder wall and cause infection. The Man- nose-bound  bacteria is
readily excreted in the urine. Mannose is orally absorbed and can be given
as a drink, capsule or tablet.
Dosage: For maximum effect, take 1.5-2.5 gInS (one level teaspoon of WRI
D-Mannose is approximately 2 grams) every 3-4 hours during waking hours for
48 hours.  Repeat as necessary.
-------Original Message-------
From: Corie Jones
Date: 04/19/05 22:07:59
To: [EMAIL PROTECTED]; quad-list@eskimo.com
Subject: Re: [QUAD-L] D-Mannose
What is Mandelamine?  I'm not sure if the bug is e-coli because I haven't
had it tested by my urologist, but I do know that d-mannose won't work if 
it
s not e-coli.

Thanks, Corie
----- Original Message -----
From: [EMAIL PROTECTED]
To: [EMAIL PROTECTED] ; quad-list@eskimo.com
Sent: Tuesday, April 19, 2005 11:18 AM
Subject: Re: [QUAD-L] D-Mannose
If your problem is e-coli, d-mannose may work. I'm not a proponent of
indwelling catheters but since that is what you are dealing with, I'd
suggest you make your bladder inhospitable to any bacteria. High doses of
vitamin C can make your urine acidic. If you take Mandelamine with vitamin 
C
 you may avoid most infections. The trick is to drink like a fish and 
check
your urine ph level.

hope that helps
John
P.S.you need a script for the mandelamine