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I feel like I'm butting in here, Corie, but I hope my last
lengthy email wasn't too boring. I've just HAD IT with UTIs.
And my last resort may be to go back to irrigating daily with a
vinegar/water solution. I'm having sludge again. Not as bad
as 6 yrs ago but still.
I, too, am going to look up Mandelamine
I had asked people if they kept track of WHAT TYPE OF BUG they had
and WHEN.
Corie ... Why haven't you got a culture & sensitivity done yet
since you're symptomatic? (remember to tell whomever takes your
sample to the lab to write "DO SENSITIVITIES REGARDLESS OF
GROWTH")
Also, we've been out of touch privately for awhile (been one crisis
after another here for a year!). Have
you been having more urine problems of late? I have a slew of free
cell minutes and would love to talk to you again at a convenient
time.
The thing that scares me the most is this article (below) on
antibiodics & D-Mannose, etc (I see I saved it in my notes on
March 9th, 2003! But didn't copy the source. I'm sure it came up
in my google search results) The resistance to antibiodics is
increasing and I had no REAL worries until I got the bug Proteus (evil
incarnate) AND Cipro doesn't do anything for me anymore.
Note below in the article too that D-Mannose can be injected
directly into the bladder too. But if it's not E-coli ...
useless.
Best to find out what bug is in your
urine before even trying Mannose or Mandelamine.
"Urinary tract or bladder infection is both a painful
condition and a major cause of doctor visits. Every year 6 million
Americans suffer at least one occurrence of this common problem and 20%
of this group experience more than one episode. Antibiotics are
routinely used for 10 days or longer to combat the infection and provide
relief.
Unfortunately, there is growing evidence that the sought
after relief is getting harder and harder to achieve for three very
important reasons:
1. Only a few of the commonly used antibiotics
achieve adequate levels in the urinary tract to be fully effective; 2.
The infection causing bacteria attach to the mucosal wall of the bladder
making removal difficult; and 3. Infection causing bacteria are becoming
increasingly resistant to antibiotics. The third reason points out the
growing concern that comes with the use of antibiotics. Pathogenic
bacteria are becoming resistant. Recent data indicates that 20% of the
patients admitted to a New York hospital are resistant to standard
antibiotic therapy. The problem is even greater in the rest of the
world, especially third world countries.
With respect to the first reason, there is little we can do
to increase the level of antibiotics in the urinary tract. The second
reason, however, offers the potential means to maintain urinary tract
health and reduce the ultimate use of antibiotics. It stands to reason
that, if the bacteria cannot attach to the mucosal wall of the bladder,
they will pass from the body in the urine and no infection will occur
.We know that the most common bacteria involved in urinary tract
infections is E. coli. We also know that E. coli is mannose
sensitive.
How does this relate to maintaining urinary tract health?
E. coli tend to bind to the epithelial tissues on the interior surface
of the bladder. This ability of E. coli to bind to bladder tissue
provides a home for subsequent growth and infection. In the presence of
Mannose, E. coli exhibits a greater affinity for the Man- nose than the
epithelial surface of the bladder. The net result is that the E. coli
either rapidly detaches from the bladder wall and attaches to the
Mannose or attaches to the Mannose before it can attach to the bladder.
The freely floating E. coli (attached to the Mannose) is now readily
eliminated on urination.
If the preceding is true, why hasn't Mannose been used
routinely for maintaining urinary tract health? Apparently, the reason
for this can be found in a single paper published on the use of Mannose
in one patient. The authors of this case report erroneously reported
that Mannose was not orally absorbed.
It was not until 1997 that Dr. Hudson Freeze published a
clarifying paper showing that Mannose is orally absorbed in both normal
individuals and patients with Carbohydrate Deficient Glycoprotein
Syndrome. His work showed that supplementation with Mannose increases
blood levels in a dose dependent manner. Peak blood levels are observed
after 1-2 hours with a clearance halftime of 4 hours. Clearance speed is
critical to how quickly Mannose will reach the bladder. No side effects
were observed. Dr. Hudson concludes, "These results establish the
feasibility of using Mannose as a potential therapeutic dietary
supplement."
What is Mannose/D-Mannose? It is a carbohydrate sugar with
a molecular weight of 180.16. Its low molecular weight and water
solubility are keys to its rapid absorption and excretion. Man- nose is
naturally produced in the body.
Supporting Evidence for the use of Mannose as a supplement
to maintain and support urinary tract health follows:
A. Adherence of E. coli was inhibited by Mannose [1. Med
Microbiol1982 Aug 15 (3):303-16] B. A 10 % solution of Mannose injected
directly into the bladder significantly Reduced bacteriuria within I day
( efficacy is dependent on concentration of Mannose & bacteria)
[Urol Res 198311(2):97-102] C. Irrigation of the bladder with 6% Mannose
inhibited bacterial adherence: " As 6% Mannose effectively inhibited
type 1 pili and also had some antibacterial activity, it may reduce
urinary tract infection if used as irrigation solution." [Urol Res 1993
21 (6):401-5 U. of Basel Switzerland- Urology Clinics, Gasser T.C.] D.
P-fimbriated E. coli is the most prevalent microorganism in acute un.
... P-fimbriated E. coli is Mannose sensitive (readily attaches to
Mannose). [J. Chemo- therapy 1999 Oct; (5):357-62] E. Mannose inhibition
of the adherence of E. coli is dose dependent. ...With the maximal
inhibitory dose, adherence was reduced by approximately 80%. (Invest.
Urol. 1981 Mar: 18(5):364-70F] F. Mannose inhibits E. coli adherence to
urinary bladder epithelium. [Urol. Res. 1985 13(2):79-8 ] G. Mannose for
Bladder and Kidney infections -Jonathan Wright M.D., Townsend Letter for
Doctors & Patients, 1999 July p.96-98
Summary: Mannose, taken as directed, can help maintain a
healthy urinary tract by binding with infectious bacteria like E. coli
before it can attach to the bladder wall and cause infection. The Man-
nose-bound bacteria is readily excreted in the urine. Mannose is
orally absorbed and can be given as a drink, capsule or
tablet.
Dosage: For maximum effect, take 1.5-2.5 gInS (one level
teaspoon of WRI D-Mannose is approximately 2 grams) every 3-4 hours
during waking hours for 48 hours. Repeat as necessary.
-------Original
Message-------
Date: 04/19/05
22:07:59
Subject: Re: [QUAD-L]
D-Mannose
What is Mandelamine? I'm not sure if the bug is e-coli
because I haven't had it tested by my urologist, but I do know that
d-mannose won't work if it's not e-coli.
Thanks, Corie
----- Original Message -----
Sent: Tuesday, April 19, 2005 11:18
AM
Subject: Re: [QUAD-L]
D-Mannose
If your problem is e-coli, d-mannose may work. I'm not a proponent
of indwelling catheters but since that is what you are dealing with, I'd
suggest you make your bladder inhospitable to any bacteria. High doses
of vitamin C can make your urine acidic. If you take Mandelamine with
vitamin C, you may avoid most infections. The trick is to drink like a
fish and check your urine ph level.
hope that helps
John
P.S.you need a script for the mandelamine
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