Application Scientist for Rigaku Europe
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Dear colleagues,
Thanks to all who replied to my question. Among the most helpful
answers was the one from Ralf W. Grosse-Kunstleve who carried out
Protein Data Bank searches (see below).
Best regards,
Lionel
Original posting
I would be very interested and much grateful having references
Dear all
There is a 3-year BBSRC-funded post doc position available in my lab
for a crystallographer with interest and experience of protein complexes.
This post is part of a larger, pan-European partnership using a 'systems'
approach to studying the transition from vegetative growth into
station
X-ray Crystallographer
Sareum is a Structure-based Drug Discovery company, based in Cambridge
UK, developing therapies for unmet medical need in cancer.
By joining Sareum you will become part of a fast growing research
company with the opportunity not only to build a well valued
Posted by request from COMCIFS for the information of software
developers interested in possible future directions for CIF.
-
Adoption of a next generation dictionary definition language: DDLm
-
A 4 year NIH funded post-doctoral position is available for studies on the
yeast F1 ATPase.
Years 1 and 2 are at Oxford University entailing single molecule studies.
Years 3 and 4 are at Rosalind Franklin University in N. Chicago using X-ray
crystallography to solve structures of mutant forms of
Hi Bernhard
This subject has indeed come up repeatedly and it has never in my view
been clearly explained why the optimal RMS(calc-target) geometry value
(i.e. bond length, bond angle etc.) in restrained refinements must
always be <= RMS(obs-mean(obs)) = SD(obs) from unrestrained refinements,
assu
Hi all.
I'm currently refining an Fab structure. All was going reasonably
well until I renumbered the PDB according to the Kabat numbering
convention. After which, REFMAC does not refine the inserted residues
properly (ie. residues 82A, 82B, 100A, 100B, 100C, etc.). It refines
these re
Hai All,
Thanks for all the good suggestions.
These are the ideas I received .
Growing crystals at different temperature, 4 C, 15C,21C and 10C.
Add glycerol or ethylene glycol - set a screen with your condition as basis,
and % EG/glycerol across - from 1% to 15% in suitable increments
Find additiv
I'm searching for examples of protein structures with a bound
palladium ion.
A ligand search on RCSB returns only a single structure (1KS4). Hard
to believe
that there should not be more examples out there.
Does anybody know of any examples off hand?
Klaus
---
A common lament on Kabat fabs.
You need to modify the LINK statement for this purpose
for the residues in question.
Read the REFMAC log and PDB and you will
see that it recognized the link but still did not use it.
The correct format for the link statement
needs the 'gap' in the pdb file refmac
Thank you for the replies everyone.
I ended up removing NCS in refmac, and that seems to have corrected
the problem. Now the inserted residues (100A, 100B, etc) seem to have
refined properly, so I guess it was an NCS issue trying to put all the
similarily labelled residues to the same spot.
It looks like a bug. Insertion code should have been used in NCS
restraint definitions. It seems it does not. I will try to fix
it asap.
Insertions are usually no problem. Problems arise when you have
deletions (i.e. residue numbering is
not sequential). Then you need to use LINK record with
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