Rien,
It would be best to wait for the next PCR result. It could be
undetectable again. But if it continues to rise, the mutation
analysis would be useful. But approximately 30% of Gleevec failures
are due to other reasons, so it is not always the complete answer. A
rising PCR would suggest th
Jeannine,
I think your approach is reasonable, but only for a limited time
period. If it were me, I would start back on 200mg per day. If you
wait for a positive PCR, then he will go back on 400mg. 200mg could
keep him negative.
--~--~-~--~~~---~--~~
[CMLHope]
A
It seems that confusion over avoiding green tea for people taking CML
TKI drugs (Gleevec, Sprycel, Tasigna) has come from a couple sources.
One is apparently anecdotal information from a few doctors who have
CML patients who drink green tea, which is a very unreliable source of
data without some s
You should have a Kinase Mutation Test done to determine if a BCR-ABL
mutation has occurred that causes the drug to stop working. Without
this test your Onc is only guessing about the cause. Here are a
couple links to descriptions of the test:
http://www.bloodctrwise.org/bins/site/content/publi
Here is some information that could help put the diagnosis into
context:
http://ubb-lls.leukemia-lymphoma.org/ubb/Forum17/HTML/001519.html
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You
Recent studies have shown that Gleevec may actually be beneficial
against osteoporosis. They found that although Gleevec seems to
decrease the levels of certain minerals used in the bones, bone
formation is actually improved. The studies do not measure all
aspects of bone health, but the studies
A wind turbine generator blade for electrical power generation.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You received this message because you are subscribed to the Google Groups
"CMLHo
It is not common, and you are right to seek immediate advice from the
doctor.
This Mayo Clinic site says it can be a side effect, but check with the
doctor immediately:
http://www.mayoclinic.com/health/drug-information/DR601855
This Canadian site actually says to stop taking Gleevec if blood in
Geeta,
There are many new CML drugs in development. I think I saw the one
described in the Indian news, but it was not for CML. I counted at
least 17 new CML drugs in development that were discussed in the
American Society of Hematologists annual meeting held this month.
There are currently 3 p
I don't know of anyone. It just started Phase I clinical trial in
May 2008, so not much data available. But AP24534 is a kinase
inhibitor that apparently works against the difficult T315i mutant
that none of the existing CML drugs work against. So that makes this
an important clinical trial.
Itching has its roots in how Gleevec works. Gleevec affects fast
growing cells, such as leukemic cells (very fast growing cells).
Other fast growing cells affected by Gleevec include hair follicles.
Gleevec affects how hair grows, and along with it comes an itch. This
hair follicle itch is diffe
You have an excellent Onc. If it were me, I would ask Dr O'Brien to
do a Gleevec Blood Level Test to see how much Gleevec is getting into
the cells while on 800mg. If the blood level is high on the 800mg
dosage, then I would ask her to cut the dosage to 400mg and stay there
indefinitely, seeing
Monosomy 7 is one of the most common secondary chromosome issues for
those with CML, and it is normally transient (comes and goes). If the
Monosomy 7 is confirmed by re-testing, an important question to ask
the Onc is whether the Monosomy 7 is showing up in the Ph+ (leukemic)
cells or in the Ph-
The Leukemia & Lymphoma Society (L&LS) just started offering co-pay
assistance for CML patients. Here is the link:
http://www.leukemia-lymphoma.org//all_page.adp?item_id=452658
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
Nike founder Phil Knight has given $100M to the OHSU Cancer Center,
with nearly all of it going to Dr Brian Druker's research. Dr Druker
was the driving force behind the discovery of Gleevec, and a leading
CML expert:
http://www.ohsu.edu/xd/about/news_events/news/cancergift102908.cfm
http://www.
Gleevec can affect the eyes by causing eye bleeds on the retina that
will cause vision problems. I understand that it can also cause some
other eye issues. I had an experience where I could not see a certain
portion of what I was looking at through one eye for several minutes.
I was able to look
Generally, Gleevec does the same things to children that it does to
adults. But that lack of long term history with the drug prevents
knowing what will happen over a very long term. But then, 7 1/2 years
plus the clinical trial period of several more years does provide a
lot of evidence that Gle
The difference of opinion mainly comes from a relatively short history
of Gleevec, some 7 1/2 years now. That lack of history makes many
Oncs nervous about predicting very long term success of the CML drugs,
even though they show great results so far. BMT has become a last
resort for adults, but
It seems clear that your PCRs are increasing steadily, and a 1 log
increase will usually suggest that the issue should be investigated.
I would ask your Onc to perform a Kinase Domain Mutation Analysis
(also known as a Gleevec Resistance Test), and ARUP Labs does this
test. Here is a link:
http:/
You might want to ask your Onc if you could split your dosage, and
take 200mg morning and evening. That has helped minimize my side
effects, and I have been PCRU on this regimen for over 2 years. The
400mg pills break in half easily, but I ask for the 100mg pills so I
can take 2 at a time.
Othe
I see from a previous posting that you were 36/1000 in Nov 2004, and
then you went to 3.4/1000, and now are back to 25/1000. Most Oncs
will give the PCR results as a percentage, and I can't be sure about
converting your result to a percentage, but your current result is
probably 2.5% -- ask your
I would suggest that you start a new post and use a different title.
Very few people here would see your posting under this title. There
are several here who have had a BMT.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
We all would like to see the PCRs drop steadily, but sometimes they
don't. Your son's PCR is only up very slightly, so I would not call
this a big setback. You will want to see the next PCR number before
you get concerned about it, since it could easily start to drop
again.
--~--~-~--~--
Timothy,
Per your question above, here is some info on phosphate levels and
bone health related to Gleevec:
http://www.gistsupport.org/ask-the-professional/gleevec-and-bone-health.php
I would be very interested in seeing the source for the liver toxicity
data you cited since it does not track wit
I believe that the Department of Haematology, Imperial College London,
London, UK does CML Kinase Domain Mutation testing and PCRs.
http://jcp.bmj.com/cgi/content/abstract/61/7/863
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
Sheila,
FDA still only allows Sprycel and Tasigna to be prescribed after
Gleevec has been tried first. That will probably change in the near
future, since several studies have shown they would all be effective
as first-line therapies for CML.
http://www.eurekalert.org/pub_releases/2007-12/uotm-dn
Here is the FDA warning:
http://www.fda.gov/medwAtch/safety/2008/epo_DHCP_03102008.pdf
Since Procrit and other anemia drugs are mainly used by people on
chemotherapy, you and your doctor would need to discuss whether the
risks cited by the FDA apply directly to your situation, and whether
those
Here is a guide that many Oncs use for managing CML, especially when
there are issues such as loss of response:
http://www.nccn.org/professionals/physician_gls/PDF/cml.pdf
See page 12 for your issue of increasing PCR numbers.
If you are only slightly positive then waiting for another PCR might
b
If the increases are less than 1 log (for example from .007 to .07 is
a 1 log increase), then Oncs do not normally tend to suggest a
change. If the increases are miniscule, then there is no cause to be
overly concerned.
Was a Gleevec "resistance test" done to determine why Gleevec stopped
workin
No wonder it makes you sick. Just reading about it made me want to
throw up:
http://en.wikipedia.org/wiki/Kayexalate
It is basically powdered plastic and is used as a binder to make
cement stronger. When taken internally, it takes in potassium and
calcium and puts out high levels of sodium (sal
Allopurinol is only needed during the first 2 or 3 weeks of taking
Gleevec or other CML drugs, for the reasons Chuck stated.
http://www.answers.com/topic/allopurinol
It will not help your current condition unless you have gout or high
uric acid levels for some reason.
--~--~-~--~~
The problem is that Aranesp, Epogen, and Procrit -- three common drugs
used to treat anemia and platelet problems -- have been under attack
from the Food and Drug Administration because they have caused
problems for some patients. Insurance companies are responding to the
FDA warnings about these
You can read about excess potassium issues (also called Hyperkalemia)
at this link:
http://en.wikipedia.org/wiki/Hyperkalemia
Hyperkalemia can be associated with kidney issues, so you should ask
your doc to check for any kidney issues.
It can also occur when a person has high platelets, as you h
CML causes fatigue for a couple reasons. First, although there are
lots of white cells, most are leukemic cells, and they are
dysfunctional. That is, they are not able to carry out their required
functions very well. Leukemic WBCs essentially do not mature enough
to work very well. Secondly, b
Sounds like you have become resistant to Gleevec. You should ask your
Onc to perform a Gleevec resistance test (also called a Kinase
Mutation Test).
Here is one lab's description of the test:
http://www.aruplab.com/TestDirectory/resources/TechnicalBulletins/BCR-ABL1%20Kinase%20Domain%20Mutation%2
Generally, as you have noted, you have slightly high WBCs, which are
mainly due to a high neutrophil count (neutrophilia). Since you have
increased Gleevec dosage to 600mg somewhat recently as I recall, you
could expect some CBC issues, but normally you would expect the WBC to
drop, not increase.
That is still an outstanding result. In log reduction terms, probably
a 4 log reduction. Sometimes a PCR test finds the needle in the
haystack. I donated blood for CML research at NIH where they did 15
separate PCRs on one tube of blood. I had been PCR undetectable for
nearly a year at that ti
While you are waiting for replies from others using Tasigna/Nilotinib,
here are links to searches for previous discussions about it on this
Board:
http://groups.google.com/group/CMLHope/search?hl=en&group=CMLHope&q=nilotinib&qt_g=Search+this+group
http://groups.google.com/group/CMLHope/search?hl
Besides the low dosage issue, you might also want to ask the Onc to do
a "Mutation Analysis" to see if Jim has become resistant to Gleevec.
If so, he would need to switch drugs. Here is a discussion of this
test:
http://www.aruplab.com/TestDirectory/resources/TechnicalBulletins/BCR-ABL1%20Kinase%
Given your zero PCR, it seems unlikely that the MRI "infiltrate" is
from the CML. I would go to a spine specialist to sort out the
issue. It could be several things unrelated to CML. The MRI
conclusions could have been skewed by knowing that you have CML and
making assumptions.
--~--~-~
Relapse occurs in approximately 10 - 20 percent of patients
transplanted during the chronic stage of CML, and a higher percentage
of patients transplanted in later stages. As Julie indicated,
generally the first thing the docs should try is a Donor Leukocyte
Infusion (more blood cells from the si
Rien,
Bob has given you the answer your doc would likely give, so it is the
right answer. So remember that as you read the next paragraphs.
But just FYI, there are other recommendations out there.
The following link says about Gleevec: "Grapefruit, grapefruit juice,
and caffeine-containing prod
Livia,
They are the same thing. Pegasys is a brand name for Pegylated
interferon-alpha-2b. Pegylated interferon-alpha-2b is simply a longer
lasting form of interferon-alpha-2b. The "PEG" in Pegylated stands
for polyethylene glycol (PEG), which is added to prolong the effects
of the interferon-a
Hand cramps (or any muscle cramp) can be caused just by the Gleevec --
it does not require interaction with anything else. I often need to
pry my fingers off an object with the other hand. Writing and using
tools will often cause hand cramps. I would see if he can alter his
utensil holding tech
We appreciate the update on Rachel. Most of what you described would
generally be attributed to the chemotherapy, especially since she has
mostly stopped taking Gleevec about a year ago. The evidence of
Gleevec causing delayed puberty seems to be inconclusive, but it
cannot be ruled out complete
Giant platelets are those which are approx 7 - 10 times normal size.
They do not function very well, so if there are large numbers of them
in the blood, you could bruise and bleed more easily. I would ask if
they were present in small or large quantities. If there are only a
small number, then
Jeanie,
Increasing the dosage of Gleevec will often suppress the counts of the
granulocyte cell lines (neutrophils, eosinophils, basophils), but will
not normally affect the lymphocyte cells (T-cells, B-cells, etc) by
creating either smudge cells (fragile lymphocyte cells that break open
easily) o
Novartis has several patents on Gleevec, but generally the main patent
expires in 2015 (it was extended from the original expiration date of
2013). As mentioned, it was granted "orphan drug" status, meaning that
since it has a relatively small population that requires such a drug.
Patent law is mo
Here is a recent article with the latest thinking on monitoring CML
patients, including BMBs. Look especially at the paragraph titled: "A
hybrid approach":
http://bloodjournal.hematologylibrary.org/cgi/content/full/111/4/1774
--~--~-~--~~~---~--~~
[CMLHope]
A sup
I think Daniel is reflecting what most of us see happening. Namely,
the 12 month BMB for patients who are responding well seems to be
disappearing, even though some continue to cling to the more
conservative approach of doing a BMB every 12 months. Dr Druker's
patients report that he stretches B
It is likely too early to tell. You will need to give it a few weeks
to know for certain if you cannot tolerate Sprycel. Even then, some
need to start-stop-restart if the first response on the new drug is
not positive. You could also experiment taking it with either a
little or lot of food, and
Daniel,
Just to add a couple items. BMB certainly looks for things that PCR
and FISH cannot see, as outlined above. The best uses of a BMB are at
diagnosis (where it is very necessary) and after that for early
detection of additional chromosomal mutations that might infer
potential disease progr
Just to clarify, the survey says that CML patients from the USA do not
qualify. I assume this is only for Canadians.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You received this message
That is very good news -- thanks for updating your progress. The
previous 4% positive FISH would seem to be a false positive reading.
ARUP labs is a large, international lab. PCR results cannot be
compared directly among labs, especially when different control genes
are used. G6PDH is not used
Here are some previous discussions about disability and CML:
http://groups.google.com/group/CMLHope/search?hl=en&group=CMLHope&q=disability&qt_g=Search+this+group
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
The G250E mutation is one of the common bcr-abl mutations that limits
Gleevec effectiveness, so a change is necessary. Both Sprycel
(Dasatinib) and Tasigna (Nilotinib) work well against it. From what I
have seen, Sprycel worked somewhat better in clinical trials for this
mutation (see 2nd articl
Your results are more than a 4 log reduction and at the low end of
detectability. It is certainly reason to celebrate.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You received this message
Maybe a short overview is warranted. Leukemia is a blood cancer.
Cancer has two things in common -- certain cells in the body become
abnormal, then the body produces large numbers of abnormal cells. In
leukemia those abnormal cells are blood cells. When leukemia affects
the lymph cells, it is cal
The IRIS Study has shown that Gleevec is far superior to the previous
drugs. Even if people initially responded to Interferon, Ara-C, and
Hydroxyurea, these responses were not as deep and durable as with
Gleevec, so long term survival rates were poor when compared to the
95% overall survival rate
More useful information:
Interview 2008 With Dr Cortes, MD Anderson:
http://www.medscape.com/viewarticle/568343?src=mp
Multiple Articles on CML Issues:
http://www.cancerpublications.com/newsletter/hematological/clm_journal/v7s2/index.html
--~--~-~--~~~---~--~~
[CM
A recent CML video presentation (Dec 2007) by Dr Jerald Radich, Fred
Hutchinson Cancer Research Center, is worth viewing:
http://www.medscape.com/viewarticle/564100
Here are abstracts related to CML from the annual meeting of the
American Society of Hematology (ASH) held in Nov 2007 (thanks to th
Jeanie,
Regarding your confusion about conflicting tests, Timothy's excellent
analysis indicated that the flow cytometry test showed nothing
unusual. This is good news, of course. But that does not mean your PCR
would be negative. Your previous posting said your BMB FISH recently
came back positiv
You might be able to have the quantitative PCRs done in Europe more
easily (possibly France, due to embargo on Iran by some countries,
including USA). Also, shorter shipping times help ensure a more
accurate result.
Here are some labs in France that deal with CML:
Laboratoire de Cytogénétique M
A 4% positive FISH could possibly be a false positive, since it has
approx 5% margin of error. But you should not assume that is the
case, but should have a PCR done, and a BMB is also a good idea if you
have not had one recently. You might also want to have a Gleevec
Resistance Test, since that
Deb (and others),
Here are some online resources to help understand the transplant
process and issues:
http://www.cancer.gov/cancertopics/factsheet/Therapy/bone-marrow-transplant
http://www.bmtinfonet.org/bmt/bmt.book/toc.html
http://www.mdanderson.org/departments/bmt/display.cfm?id=D176629C-8
For those of us who have followed Jonathan's story it is very
heartening to hear that he is growing and doing well. Thanks for
letting us know.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
Sometimes it helps children to understand that they are not alone, and
that other children share their same problem. Approximately 3800
children are diagnosed with all types of leukemia each year in the
United States, and many more around the world. There are over 1000
children and teens with CM
Between the Gleevec side effects and Lupus, no wonder you are
fatigued. Both suppress WBC, RBC, and platelets. Hopefully your Onc
has stopped your Gleevec until your platelets recover. Sometimes a
Gleevec vacation will get things back on track. But if it does not
straighten out soon, then I wo
A search of CMLHope gives the following references for discussions
about specialists:
http://groups.google.com/group/CMLHope/search?hl=en&group=CMLHope&q=specialists&qt_g=Search+this+group
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
--
Livia,
You said that your current PCR is 0.4/1000 and was previously
0.1/1000 Your Nov 26th posting said "My result from May said 0.1
copies per 1,000 copies ABL. The PCR from August that I received today
said 0.4 copies per 1,000 copies ABL." Lab results are not normally
displayed in these wa
Gleevec can interfere with bone strength, especially those taking
higher doses. It is probably a mixture of already having a problem
with osteoporosis and Gleevec making the problem worse.
http://www.spine-health.com/news/osteoporosis/art532621.html
--~--~-~--~~~---~-
A reduction to 400mg would seem reasonable as long as he did not have
an initial reason for the 600mg dosage, namely that 400mg was not
doing the job. I would definitely ask the Onc about reducing the
dosage to 400mg.
--~--~-~--~~~---~--~~
[CMLHope]
A support group
Going off drug therapy will most likely result in relapse for the
majority of folks with CML. But a few have done it and have remained
free of CML, some of them for years. The reason is not clear. There
was a clinical trial in 2005 that took 12 people off Gleevec who had
been PCR undetectable for
Mel,
Being bounced around from Gleevec to a Tasigna trial and then to
Sprycel, and having Trisomy 8 is not the way you would like to have
things go, so the distress is understandable. From your previous
postings the good news has been your low blast count, which means you
had not advanced to the
Genzyme Genetics is the only lab I know of that does this test. Here
is their website:
http://www.genzymegenetics.com/testmenu/tests/cancer/gene_p_testmenu_can_test_BCRABL.asp
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
The plastic and dioxin part is an old Urban Legend that is false. The
rest has grains of truth mixed with fabrications.
http://urbanlegends.about.com/library/bl-microwave-dioxin2.htm
This proves once again that the Internet is both a source of good and
bad information.
--~--~-~--~~
Probably. Most expiration dates are set by lawyers. It won't harm
you, it just starts losing some effectiveness as it ages.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You received this
Livia,
It is difficult when so many things are coming together at the same
time. In percentage terms, your PCR went from .01% to .04%. When the
results are shown in that way, they do not look as bad. Shortly you
will have the results of the PCR from the sample taken yesterday, and
that will pro
I felt fine -- no additional side effects beyond what Gleevec caused
me. For the NIH trial there is one vaccine shot in each arm at the
same time, since there are two different vaccines being used.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.c
Livia brought up the issue of vaccine clinical trials in her recent
posting. I was a participant in a clinical trial in early 2007 that
involved research on a leukemia vaccine. This was a Phase I trial,
which essentially checked to see if the substance was safe enough to
try on a larger number of
Livia,
The WBC count is within the normal range, and it can fluctuate because
of allergies or low level bacterial infections. I would not be too
concerned about that, and would wait to see what the PCR test results
are. We wish you the best results. The low RBC count is a problem
for many of us
In mathematical terms, .1 equates to 1 in 100,000, and .01 is
1 in a million. But PCR values should be expressed as percentages, so
if the PCR reads .0001%, that is 1 in a million. The theoretical
limit of RT-PCR sensitivity is .0001% (1 in a million). So using RT-
PCR, PCRU is less tha
In simple terms, Osmolality refers to the level of concentration of
something suspended in solution, such as calcium levels in the blood
plasma. It is like putting sugar into iced tea; the sugar disappears
as it is suspended in the liquid.
http://www.nlm.nih.gov/medlineplus/ency/article/003463.h
Rob,
Second request -- need to block this guy. Are you there??? This
website will not work without monitoring and taking action to enforce
the rules.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
--
Gleevec not only suppresses leukemic cell production, but it also
mildly suppresses normal blood cell production. Many of us on Gleevec
have blood counts at the low end of normal (or lower than normal). If
your red blood cell (RBC) counts, HGB, and/or HCT are below mid-range
normal, it will impa
Rob,
Please block this Ankur Kothari guy for violating posting rules.
Thanks.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You received this message because you are subscribed to the Googl
Some guys with CML taking Sprycel have reported that issue. Not sure
about Gleevec.
http://www.newcmldrug.com/bms_discuss/reply.asp?ID=4809&Reply=4809
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
Jerome is doing great. PCRU is only attained by fewer than 10% of
CMLers. A 3 log reduction is used as the CML therapy goal, which is
more realistic. And studies show nearly 100% survival rate if 3 log
reduction is achieved. So Jerome has exceeded the goal.
His anemia is something that many o
Overall the report is not bad. Except for the platelet issue, the
rest is not a big concern.
"Moderately hypercellular marrow" (more cells in the marrow than
normal people have) is fairly normal for CML types, even those who are
doing very well. I am PCRU and my report says that sometimes.
"No
There have been several requests for information about the various
tests done on folks with CML. This is designed as a general overview
to provide a basic layman's understanding of testing and CML. I will
avoid the jargon and keep this somewhat short, so this will not cover
everything in detail. F
I believe you were diagnosed in early 2004. FISH tests are often used
in combination with a BMB at diagnosis. After that, FISH can be used
until it no longer registers positive. Then the PCR is used for
monitoring since it is far more sensitive. Some Oncs have stopped
using FISH at all and jus
Previous postings on this issue are interesting to review for context:
http://groups.google.com/group/CMLHope/browse_thread/thread/f5e7e20690a74dd4/6a8c3215350f751e?lnk=gst&q=Richard+H&rnum=1#6a8c3215350f751e
--~--~-~--~~~---~--~~
[CMLHope]
A support group of htt
Gleevec can make some more likely to experience dizziness, but there
are many other reasons. Low red blood cell/HGB/HCT counts are one, as
Livia mentioned, since there is reduced oxygen in the blood, so the
brain can become low on oxygen. But allergies are one of the most
common causes. Throug
My response should have said more clearly that the five alleles are in
pairs, which is where the number 10 comes from.
--~--~-~--~~~---~--~~
[CMLHope]
A support group of http://cmlhope.com
-
You received this messag
For BMT matching, at least five different proteins or alleles, called
Human Leukocyte Antigens (HLA), which reside on the surface of our
cells, are used to match a donor. Allele matching is important to
survival, since the body is continually invaded by foreign organisms
that must be identified a
Regarding mutations and progression to Accelerated Phase, the most
recent thinking on the subject seems to lean toward saying that if the
mutations are not accompanied by increased blasts (above 10%), then it
is not Accelerated Phase. I believe that is what Dr Shah is saying.
Here is the Wikiped
ups.google.com/group/CMLHope/search?group=CMLHope&q=sprycel&qt_g=Search+this+group
We all hope Erik will do very well on Sprycel, as many others are
getting good results with it.
--Trey
--~--~-~--~~~---~--~~
[CMLHope]
A support
Livia,
Here is the summary report on the Phase I clinical trial of this
vaccine you are considering:
http://meeting.jco.org/cgi/content/abstract/24/18_suppl/6509?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=vaccine+cml&searchid=1&FIRSTINDEX=0&volume=24&issue=18_suppl&resourcetype=HWCIT
K562
Novartis has several patents on Gleevec (Imatinib), but generally the
main patent expires in 2015 (it was extended from the original
expiration date of 2013).
Bristol Myers Squibb has five patents on Sprycel (Dasatinib). The
main patents expire in April 2020.
Novartis has filed a patent for Tas
Actually, just as Gleevec is the marketing name used by Novartis, and
also still has the generic technical name Imatinib, Tasigna is the
marketing name, and Nolotinib will continue to be the generic
technical name. Same for Sprycel and Dasatinib. When the patents
expire for each (a long time), t
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