Hmmm, this is very interesting. Sally Garnet <garnetri...@earthlink.net> wrote: It may not be called the MDR1 or be a single gene but there is a proven genetic component (Irish, English Native American populations) to multiple chemical sensitivity which could be said, in a broad sense to cover this type of sensitivity. MCS is a condition with many factors, some of which are the porphyrin enzyme systems or lack there of a component to be more correct -- this is thought to be genetic, could be induced and also may be sex linked with women showing greater tendencies. Also MCS relates to liver function, total load, Kindling (sensitivity in brain centers to molecule quantities of VOC that access the brain directly through the Olfactory and Trigeminal cranial nerves in the nasal septum, Bell et al). Also complicated by IgE mediated Type I Allergy, and poorly functioning or sensitized immune systems.
In the case of the MDR1 gene it likely involves the ability to metabolize the agent. We know that sight hounds are very sensitive to anesthetics, however, this is due to their lack of body fat where the agents depot from the systemic circulation -- less body fat means higher blood levels. I am not sure though if they have shown a slower metabolism in sight hounds for these agents as well. Garnet On Thu, 2004-10-21 at 11:26, Sally Khanna wrote: > Garnet, > > Is this gene exclusive to dogs, or is it found in humans also? > > Sally > > Garnet wrote: > On Thu, 2004-10-21 at 00:10, David W Kenney wrote: > > No...one person did go blind and almost caused DMSO to be > taken off the > > market totally. This all happened when they first learned of > its > > properties to relieve inflammation (and pain) in arthritis > which is how it > > was usually used. People would rub it on sore joints. It > wasn't rabbits. > > However since there have been few if any problems with DMSO > in the last 30 > > years it suggests that DMSO wasn't the etiology of the > blindness anyway. > > Rabbits are the medical model for study eye effects of > pharmaceutical > agents. Problem is that they are uniquely sensitive to DMSO so > are not > consider a valid model for humans in this instance. Dogs too > have been > reported to have some occular effects with prolonged use. I > still use > DMSO and CS in my dogs eyes, just cleared up a case of > conjunctivities > in a puppy this week by spraying 20% DMSO and CS several > hourly -- it > cleared in less than 10 hours! I did use a bit of Gentocin > ointment, > maybe two applications in between the DMSO CS spray. My 5 mo > old puppy > was so happy when her eye stopped hurting and was obviously > grateful for > the assitance. > > > > > This is much like the study of Ivomectin in animals. In the > studies of > > 10,000 or so dogs...1 collie died. So it is not approved for > collies. > > However...the average age of the whole group was higher than > that expected > > for the number of animals studied and the length of the > study...so in effect > > they could have added the wording "Extends lifespan" if they > so desired and > > would have been correct as far as the research was > concerned. And, the > > collie might well have died a natural death rather than it > being caused by > > the drug. This is a problem with any study, is it not? > > We own Australian Shepherds, a collie derived breed that > sometimes > exhibits this sensitivity. It is due to the MDR1 gene, and > individuals > with this gene are also sensitive to anesthetics, chemo > therapy agents > and other drugs. There is an inexpensive genetic test. > Something that > most well intenetioned pet owners should have done if they > have a breed > that is known to sometimes exhibit the effects of this gene. > One > certainly needs to know if a dog is sensitive to anesthetics > before > something comes up. > > > Garnet > > > -- > The Silver List is a moderated forum for discussing Colloidal > Silver. > > Instructions for unsubscribing are posted at: > http://silverlist.org > > To post, address your message to: silver-list@eskimo.com > Silver List archive: > http://escribe.com/health/thesilverlist/index.html > > Address Off-Topic messages to: > silver-off-topic-l...@eskimo.com > OT Archive: > http://escribe.com/health/silverofftopiclist/index.html > > Li! st maintainer: Mike Devour > > > ______________________________________________________________________ > Do you Yahoo!? > Yahoo! Mail - Helps protect you from nasty viruses. --------------------------------- Do you Yahoo!? Yahoo! Mail - You care about security. So do we.
