I've done work in one of the large pharma's research facility. 
Everything I have seen has been srpinkelred



At 08:12 AM 5/14/2009, you wrote:
>Being a sprinkler guy, I don't know that many pharmaceuticals that aren't
>sprinklered since we only hang around ones that are!
>
>However, I can relay that back about 25 years ago we retrofit a 100,000 sf
>existing mfg building on a large pharmaceutical campus that had a 30,000 SF
>clean room area (DIPA) for a rather phenomenal amount of money.
>
>The largest hazard was the plastic containers, but the decision to sprinkler
>the building came after a small plant renovation project erupted into a
>fireball when some flammables deposited (inadvertently)as a coating caught
>from a welder. I don't recall there being fatalities, but certainly dirty
>underwear for anyone within a 100 feet of it. Management realized the risk
>to life in addition to the experienced (and what could have been much worse
>potentially) BI. Once they decided to do it, there was no pushback on cost,
>suggestions to omit AS in any areas, etc. believe me, retrofitting operating
>sterile mfg operation ain't cheap. 3 levels of gowning, so you lost almost
>an hour for a p. All material washed down with alcohol in an airlock,
>washdown the scissors, power machine, pretty much everything but the
>blueprints. Pull the tape measure out completely and swab it down as it
>retracts.
>
>In this same building a few years later, a change in the machinery had us
>installing a head with exposed piping, SS316, maybe 10' with a couple 90's,
>and our NTE price was $5k. Brought it in for $3500 and they were happy.
>
>So while this isn't exactly what you asked for, here's a drugmaker that
>originally elected to NOT sprinkler in I think the 1960's, had an OOPS that
>could have been a lot worse, and when they realized the exposure, they
>didn't hesitate to do all it took to bring it up to the level of safety that
>should have been in place originally- at a much lower price.
>
>The cleaning crew that followed our weekend shift in the sterile area missed
>a little bit and they had to dump the first shift following's production; I
>believe it was $250,000 of drugs down the drain. Expensive cleaning crew QC,
>eh?
>
>They're smart if they learn from the mistakes of others, and save some money
>and do it right the first time.
>
>George Church
>Rowe Sprinkler
>
>-----Original Message-----
>From: [email protected]
>[mailto:[email protected]] On Behalf Of Frans Stoop
>Sent: Wednesday, May 13, 2009 8:27 PM
>To: [email protected]
>Subject: Reasons to not sprinkler a pharmaceutical plant
>
>Dear colleagues,
>
>Here is a peculiar question:
>A pharmaceutical company is planning to build a new plant with
>laboratories for production and quality control, offices and an
>underground parking level.
>The top floor is for HVAC.
>The main process is waterbased, although, like any other laboratory,
>there small quantities of flammable liquids present.
>The flammable liquids will be stored in fire cabinets.
>We already convinced the company's management that sprinkler is the
>way to go for the obvious reasons: life safety, preservation of
>property, continuity of operations, etc.
>Maybe we advised them too good:
>Now the management wonders why not all pharmaceutical plants are
>sprinklered throughout.
>
>I'm composing a list of unsprinklered pharmaceutical facilities with
>the reason why the decision makers in concern have chosen not to sprinkler.
>Can you help me with examples of such sites, (parts of) plants or
>rooms and the reasoning?
>
>By the way, this question from our client is not as peculiar as it
>looks like at first sight.
>It is just a known method of decision making.
>It might lead to the decision to protect some rooms or parts of the
>building otherwise (with gas, pre-action sprinkler e.g.).
>
>Frans Stoop
>TOS architecture & fire protection
>Netherlands <[email protected]>
>Tel. +31-24-324 0112
>
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Todd G. Williams, PE
Fire Protection Design/Consulting
Stonington, Connecticut
www.fpdc.com
860.535.2080  
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